Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Aulonocephalus pennula (1)
- Cecal worm (1)
- Colinus virginianus (1)
- Contamination (1)
- Covid-19 (1)
-
- Cross-omic (1)
- Egg yolk antibody (1)
- Enterobactin (1)
- Gram-negative bacteria (1)
- Gwas (1)
- Helminths (1)
- Human (1)
- Immune intervention (1)
- Inflammatory and autoimmune diseases (1)
- Microbiome (1)
- Microplastics (1)
- Myotis lucifugus (1)
- Northern bobwhite (1)
- PH-responsive (1)
- PITCR (1)
- Plant (1)
- Proximal TCR signaling (1)
- Rnaseq (1)
- Simulation model (1)
- Stress response (1)
- T cell receptor (1)
- Transmembrane peptides (1)
- Vensim (1)
- White nose syndrome (1)
- Publication
- Publication Type
Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
A Novel Transmembrane Ligand Inhibits T Cell Receptor Activation, Yujie Ye
A Novel Transmembrane Ligand Inhibits T Cell Receptor Activation, Yujie Ye
Doctoral Dissertations
T lymphocytes (T cells) play essential roles in the adaptive immune system. Each mature T cell expresses one type of functional T cell receptor (TCR). The TCR recognizes antigens bound to the major histocompatibility complex (MHC) in antigen presenting cells. The resulting stimulation signal crosses the transmembrane domain of TCR and initiates downstream signaling cascades. The human immune system relies on TCRs to recognize a variety of pathogens. Normally, TCR can distinguish the self-antigens from pathogenic antigens. However, dysfunction or aberrant expression of TCRs causes different inflammatory and autoimmune diseases, which afflict millions of people annually (Chapter I). Current treatments …
Exploring The Relationships Between South Texas Northern Bobwhite Populations And Cecal Worms Via System Dynamics, Nicole J. Traub, Benjamin L. Turner, Leonard A. Brennan, Alan M. Fedynich
Exploring The Relationships Between South Texas Northern Bobwhite Populations And Cecal Worms Via System Dynamics, Nicole J. Traub, Benjamin L. Turner, Leonard A. Brennan, Alan M. Fedynich
National Quail Symposium Proceedings
Community ecology historically focused on plants and free-living organisms; however, problems such as defining habitat boundaries and obtaining adequate sample sizes arise when evaluating such communities. The unique nature of host-helminth systems allows parasite community ecologists to avoid these problems when testing ecological hypotheses. Unlike free-living communities that have artificially constructed boundaries, parasite communities have well-defined unambiguous boundaries within host individuals. Due to the inherently complex and dynamic nature of ecological systems, traditional experimental methods often require expensive, long-term trials beyond investigators’ time and resource budgets. Conversely, a system dynamics approach facilitates learning about such systems via simulation of ecosystem …
Enterobactin-Based Immune Interventions Against Gram-Negative Bacterial Infections, Huiwen Wang
Enterobactin-Based Immune Interventions Against Gram-Negative Bacterial Infections, Huiwen Wang
Doctoral Dissertations
Enterobactin (Ent)-mediated iron acquisition is critical for many Gram-negative bacteria to survive in the host. Given the bacteriostatic effect of lipocalin-2 resulting from its potent Ent-binding ability, immune interventions directly targeting Ent is a promising antimicrobial strategy against Gram-negative bacterial infections. Moreover, hyperimmune egg yolk antibody is an emerging passive immune agent for the control of bacterial infections. Oral administration of anti-Ent egg yolk antibody may confer passive immune protection against Ent-dependent enteric pathogens. In this dissertation study, multidisciplinary approaches in conjunction with different model systems (in vitro, in vivo, and ex vivo) were used to …
Cat Covid, Cmv And Chemokines, Oh My!, Trevor Hancock
Cat Covid, Cmv And Chemokines, Oh My!, Trevor Hancock
Doctoral Dissertations
Cytomegalovirus (CMV) is an important pathogen infecting most humans worldwide. CMV infection within immunocompromised individuals can cause severe morbidity and potential mortality. Disease during CMV infection is due to virus dissemination and subsequent inflammation. Host immune cells lie at the intersection potentially mediating both. The CMV-encoded viral chemokine vCXCL-1 is a proposed virulence factor in mouse models increasing immune cell recruitment and disease. However, the primary immune cell mediator is undetermined. To identify targets, Chapter 2 examines CXCR2 expression (receptor for vCXCL-1) among various mouse tissues and human peripheral blood under steady-state conditions. In vitro, isoforms of HCMV’s vCXCL-1 …
Multi-Omic Systems Biological Analysis Of Host-Microbe Interactions, Piet Jones
Multi-Omic Systems Biological Analysis Of Host-Microbe Interactions, Piet Jones
Doctoral Dissertations
Systems biology offers the opportunity to understand the complex mechanisms of various biological phenomena. The wealth of data that is produced, at an increasing rate, provides the potential to meet this opportunity. Here we take an applied approach to integrate multiple omic level data sources in order to generate biologically relevant hypotheses. We apply a novel analysis pipeline to model both, in concert, the microbial and transcriptomic signature from COVID-19 positive patients. We show patients may suffer from an increased microbial burden, with an increased pathogen potential. Gene expression evidence further shows patients may exhibit a compromised barrier immunity, owing …
Microplastics Exposure In At-Risk Myotis Lucifugus Bats Of The Northeastern United States, Leah Crowley
Microplastics Exposure In At-Risk Myotis Lucifugus Bats Of The Northeastern United States, Leah Crowley
Chancellor’s Honors Program Projects
No abstract provided.