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Full-Text Articles in Life Sciences
A Study Of The Effect Of Physiological Stressors On Hypothalamic Regulation Of Reproduction Using An In Vitro System, Lisa L. Amelse
A Study Of The Effect Of Physiological Stressors On Hypothalamic Regulation Of Reproduction Using An In Vitro System, Lisa L. Amelse
Doctoral Dissertations
Stressors have a negative impact on reproductive efficiency in humans and other animals, which has an economic cost due to infertility treatments for humans and reduced income for food producers. We wished to determine the molecular pathways by which metabolic disturbances and low-level inflammation impact the hypothalamic pituitary gonadal (HPG) axis using an in vitro model. To this end, we used the GT1-7 cell line, an immortalized line expressing the Kiss1R receptor that responds to kisspeptin stimulation with the release of GnRH to assess the impact of stressors on the GnRH-releasing cells. Additionally, we used the KTaV-3 and KTaR-1[A1] …
Ethological Causes And Consequences Of The Stress Response, Neil Greenberg, James A. Carr, Cliff H. Summers
Ethological Causes And Consequences Of The Stress Response, Neil Greenberg, James A. Carr, Cliff H. Summers
Faculty Publications and Other Works -- Ecology and Evolutionary Biology
Stress involves real or perceived changes within an organism or in the environment that activate an organism’s attempts to cope by means of evolutionarily ancient neural and endocrine mechanisms. Responses to acute stressors involve catecholamines released in varying proportion at different sites in the sympathetic and central nervous systems. These responses may interact with and be complemented by intrinsic rhythms and responses to chronic or intermittent stressors involving the hypothalamic-pituitary-adrenal axis. Varying patterns of responses to stressors are also affected by an animal=s assessment of their prospects for successful coping. Subsequent central and systemic consequences of the stress response include …