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Faculty Publications and Other Works -- UT Graduate School of Medicine
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Odontogenic Ameloblast-Associated Protein (Odam) Inhibits Growth And Migration Of Human Melanoma Cells And Elicits Pten Elevation And Inactivation Of Pi3k/Akt Signaling, James S. Foster, Lindsay M. Fish, Jonathan E. Phipps, Charles T. Bruker, James M. Lewis, John L. Bell, Alan Solomon, Daniel P. Kestler
Odontogenic Ameloblast-Associated Protein (Odam) Inhibits Growth And Migration Of Human Melanoma Cells And Elicits Pten Elevation And Inactivation Of Pi3k/Akt Signaling, James S. Foster, Lindsay M. Fish, Jonathan E. Phipps, Charles T. Bruker, James M. Lewis, John L. Bell, Alan Solomon, Daniel P. Kestler
Faculty Publications and Other Works -- UT Graduate School of Medicine
Background
The Odontogenic Ameloblast-associated Protein (ODAM) is expressed in a wide range of normal epithelial, and neoplastic tissues, and we have posited that ODAM serves as a novel prognostic biomarker for breast cancer and melanoma. Transfection of ODAM into breast cancer cells yields suppression of cellular growth, motility, and in vivo tumorigenicity. Herein we have extended these studies to the effects of ODAM on cultured melanoma cell lines.
Methods
The A375 and C8161 melanoma cell lines were stably transfected with ODAM and assayed for properties associated with tumorigenicity including cell growth, motility, and extracellular matrix adhesion. In addition, ODAM–transfected cells …