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Full-Text Articles in Life Sciences
Sars-Cov-2 Impairs Dendritic Cells And Regulates Dc-Sign Gene Expression In Tissues, Guoshuai Cai, Mulong Du, Yohan Bossé, Helmut Albrecht, Fei Qin, Xizhi Luo, Xiao Michelle Androulakis, Chao Cheng, Mitzi Nagarkatti, Prakash Nagarkatti, David C. Christiani, Michael L. Whitfield, Christopher I. Amos, Feifei Xiao
Sars-Cov-2 Impairs Dendritic Cells And Regulates Dc-Sign Gene Expression In Tissues, Guoshuai Cai, Mulong Du, Yohan Bossé, Helmut Albrecht, Fei Qin, Xizhi Luo, Xiao Michelle Androulakis, Chao Cheng, Mitzi Nagarkatti, Prakash Nagarkatti, David C. Christiani, Michael L. Whitfield, Christopher I. Amos, Feifei Xiao
Faculty Publications
The current spreading coronavirus SARS-CoV-2 is highly infectious and pathogenic. In this study, we screened the gene expression of three host receptors (ACE2, DC-SIGN and L-SIGN) of SARS coronaviruses and dendritic cells (DCs) status in bulk and single cell transcriptomic datasets of upper airway, lung or blood of COVID-19 patients and healthy controls. In COVID-19 patients, DC-SIGN gene expression was interestingly decreased in lung DCs but increased in blood DCs. Within DCs, conventional DCs (cDCs) were depleted while plasmacytoid DCs (pDCs) were augmented in the lungs of mild COVID-19. In severe cases, we identified augmented types of immature DCs (CD22+ …
Physical Activity Among Adults Residing In 11 Countries During The Covid-19 Pandemic Lockdown, Kele Ding, Jingzhen Yang, Ming-Kai Chin, Lindsay Sullivan, J. Larry Durstine, Verónica Violant-Holz, Giyasettin Demirhan, Nara R.C. Oliveira, Biljana Popeska, Garry Kuan, Waheeda Khan, Jianhui Dai, Xia Xu, Zornitza Mladenova, Govindasamy Balasekaran, Gary A. Smith, Global Community Health-Covid-19 Collaborative Research Team
Physical Activity Among Adults Residing In 11 Countries During The Covid-19 Pandemic Lockdown, Kele Ding, Jingzhen Yang, Ming-Kai Chin, Lindsay Sullivan, J. Larry Durstine, Verónica Violant-Holz, Giyasettin Demirhan, Nara R.C. Oliveira, Biljana Popeska, Garry Kuan, Waheeda Khan, Jianhui Dai, Xia Xu, Zornitza Mladenova, Govindasamy Balasekaran, Gary A. Smith, Global Community Health-Covid-19 Collaborative Research Team
Faculty Publications
During the novel coronavirus (COVID-19) pandemic, physical activity (PA) behaviors were altered worldwide due to public health measures such as “lockdown.” This study described PA among adults residing in 11 countries during COVID-19 lockdown and examined factors associated with PA engagement. We conducted a cross-sectional anonymous survey among adults (≥18 years old) in 11 countries (Brazil, Bulgaria, China, India, Ireland, Malaysia, North Macedonia, Singapore, Spain, Turkey, United States). Of 11,775 participants, 63.7% were female and 52.8% were 18–34 years old. More than 40% of participants were insufficiently active (43.9%) and reported a decrease in their PA during lockdown (44.8%). Statistically …