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Articles 1 - 7 of 7
Full-Text Articles in Life Sciences
The Classification Of Basket Neural Cells In The Mammalian Neocortex, Sreya Pudi
The Classification Of Basket Neural Cells In The Mammalian Neocortex, Sreya Pudi
Senior Theses
Basket neuronal cells of the mammalian neocortex have been classically categorized into two or more groups. Originally, it was thought that the large and small types are the naturally occurring groups that emerge from reasons that relate to neurobiological function and anatomical position. Later, a study based on anatomical and physiological features of these neurons introduced a third type, the net basket cell which is intermediate in size as compared to the large and small types. In this study, multivariate analysis was used to test the hypothesis that the large and small types are morphologically distinct groups. The results of …
Ahr Expression On Rorc-Expressing Immune Cells Is Essential For I3c-Mediated Protection Against Colitis, Michal C. Williams
Ahr Expression On Rorc-Expressing Immune Cells Is Essential For I3c-Mediated Protection Against Colitis, Michal C. Williams
Senior Theses
Colitis is an inflammatory bowel disorder (IBD) whose etiology is attributed to modification in the luminal microbiota and dysregulation in the immune response. Indole is a signaling molecule which is naturally produced by gut luminal microbiota. Indole-3- carbinol (I3C) is a compound commonly found in vegetables and a ligand for the aryl hydrocarbon receptor (AhR). Previous studies have detected decreased expression and activation on the AhR receptor in colitis patients, thought to possibly alter gut microbiota metabolism, subsequently promoting colitis. 1 AhR, expressed in a variety of immune and epithelial cells, contributes to gut homeostasis by affecting vital mediators such …
A Study Of The Social, Cultural, And Environmental Influences On Appalachian Agriculture, Morganne May
A Study Of The Social, Cultural, And Environmental Influences On Appalachian Agriculture, Morganne May
Senior Theses
Appalachia, despite its rich history and abundant biological and cultural diversity, is commonly associated with a generalized notion of ignorance, resistance to progress, and "backwardness." This study aims to shed light on the socioeconomic, cultural, and environmental influences which have shaped the present food systems of Appalachia through a review of relevant literature. This history provides the necessary context to strategize a region-specific, socioeconomically and environmentally sustainable food system moving forward.
Purification And Functional Characterization Of The Iron-Responsive Transcription Factor Aft1 From C. Glabrata, Jade Ikahihifo-Bender
Purification And Functional Characterization Of The Iron-Responsive Transcription Factor Aft1 From C. Glabrata, Jade Ikahihifo-Bender
Senior Theses
Due to its unique ability to serve as both an electron donor and acceptor, iron is utilized as a co-factor for many biological processes, including electron transfer, oxygen binding, and vitamin synthesis. Iron is also a key factor during fungal infections as the human host and invading pathogens battle over limited iron pools. The primary iron-responsive transcription factor Aft1 in the opportunistic pathogenic yeast Candida glabrata responds to iron deficiency by activating expression of iron acquisition genes. However, the mechanisms for sensing intracellular iron levels and regulating Aft1 activity in response to iron are unknown. The C. glabrata iron regulation …
Lions, Tigers, And Hemes - Oh My! A Dynamic Look At The Electronic Effects Of Porphyrin Substitution On Cytochrome P450 Olet, Alexis J. Holwerda
Lions, Tigers, And Hemes - Oh My! A Dynamic Look At The Electronic Effects Of Porphyrin Substitution On Cytochrome P450 Olet, Alexis J. Holwerda
Senior Theses
OleT, a member of the CYP152 family of cytochrome P450s (CYPs), decarboxylates fatty acids using hydrogen peroxide as an oxidant. The resultant products are a terminal alkene and carbon dioxide. This C–C cleavage reaction is highly atypical for CYPs, which prototypically oxygenate substrates, and provides a potential means to enzymatically produce drop-in fuels. OleT contains a heme-iron cofactor that facilitates decarboxylation through the activation of hydrogen peroxide. The catalytic cycle, as determined by transient kinetics, includes two ferryl intermediates known as Compound I (Ole-I) and Compound II (Ole-II). Ole-I performs substrate hydrogen abstraction and subsequent single electron transfer to Ole-II …
Cyclic Fluctuations Of Zooplankton Dynamics In A Tidal Salt-Marsh Basin, Jamaal Jacobs
Cyclic Fluctuations Of Zooplankton Dynamics In A Tidal Salt-Marsh Basin, Jamaal Jacobs
Senior Theses
Zooplankton are pelagic aquatic animals that are limited in their movements by the water currents around them and are major links in aquatic food webs between primary producers and higher trophic levels. Their populations are temporally and spatially variable, as they are sensitive to changes in salinity, temperature, and dissolved oxygen. This is especially true in highly dynamic environments, like estuaries, where environmental conditions are highly variable across seasonal and daily cycles. In order to examine the variability in zooplankton populations across a tidal cycle, we collected zooplankton samples from North Inlet Estuary at 30-minute intervals over a half tidal …
Killing The Planet But Saving The People: How The American Healthcare Industry Impacts The Environment, Malorie Webb
Killing The Planet But Saving The People: How The American Healthcare Industry Impacts The Environment, Malorie Webb
Senior Theses
The American population is rapidly growing and aging. In order to accommodate such a large population and its associated challenges, the healthcare industry has had to continually expand and adapt. The United States healthcare industry is now one of the largest, most expensive components of the economy. As such, it produces vast amounts of waste. Healthcare waste can damage the environment and contribute to climate change, which in turn can contribute to worsening health outcomes in the population. This thesis aims to explore both the immediate and prolonged impacts of the American healthcare industry on the environment, as well as …