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Retinoic Acid Inhibition Impairs Planarian Eye Regeneration, Gabrielle Bennetti, Aaron Corbin-Leftwich, Linda M. Boland, Isaac Skromne
Retinoic Acid Inhibition Impairs Planarian Eye Regeneration, Gabrielle Bennetti, Aaron Corbin-Leftwich, Linda M. Boland, Isaac Skromne
Biology Faculty Publications
Retinoic acid is a known morphogen in regulating animal growth and development. Planaria are a key model system for regeneration and their eyes are a morphological marker of anterior differentiation. We explored the requirement for retinoic acid signaling in the regeneration of body parts in the planaria S. mediterranea using an inhibitor of retinoic acid synthesis, diethylaminobenzaldehyde (DEAB). Whole planaria, soaked in DEAB for three days prior to and five days following amputation, produced trunk and tail fragments with defective anterior regeneration. Following regeneration, up to 80% of posterior fragments developed abnormal eyes. The abnormalities included animals without eyes, with …