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Full-Text Articles in Life Sciences
Investigating The Main Protease (Mpro) Of Sars-Cov-2 As A Potential Drug Target, Valerie Giovina Pascetta
Investigating The Main Protease (Mpro) Of Sars-Cov-2 As A Potential Drug Target, Valerie Giovina Pascetta
Honors Theses and Capstones
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 19 (COVID-19) pandemic has claimed the lives of roughly 6.2 million people worldwide as of May 2022. The virus’s main protease (Mpro ) has been identified as an attractive drug target due to the critical role it plays in the viral life cycle. The roughly 34 kDa Mpro cleaves functional viral polypeptides out of two long polyproteins at conserved cut sites, allowing them to fulfill their role in processes like transcription and replication. Here, we have studied the enzymatic activity …
Alternative Explanation For Excision Repair Deficiency Caused By The Polaex1 Mutation, Alan F. Wahl, Joel W. Hockensmith, Stanley Kowalski, Robert A. Bambara
Alternative Explanation For Excision Repair Deficiency Caused By The Polaex1 Mutation, Alan F. Wahl, Joel W. Hockensmith, Stanley Kowalski, Robert A. Bambara
Law Faculty Scholarship
An investigation of the mechanism of the polAexl mutation in vitro suggested that the excision repair deficiency observed in vivo does not result from an inability of the enzyme to nick translate. The defect appears to reside in the inability of the enzyme to effectively generate a nick structure to serve as a substrate for DNA ligase.