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Articles 1 - 16 of 16
Full-Text Articles in Life Sciences
Identification Of Novel Biosynthetic Gene Clusters Encoding For Polyketide/Nrps-Producing Chemotherapeutic Compounds From Marine-Derived Streptomyces Hygroscopicus From A Marine Sanctuary, Hannah Ruth Flaherty
Identification Of Novel Biosynthetic Gene Clusters Encoding For Polyketide/Nrps-Producing Chemotherapeutic Compounds From Marine-Derived Streptomyces Hygroscopicus From A Marine Sanctuary, Hannah Ruth Flaherty
Honors Theses and Capstones
Nearly one out of six deaths in 2020, around ten million people, were caused by cancer, making it a leading cause of death worldwide (WHO, 2022). This major public health issue, in addition to the rise of multidrug-resistant (MDR) pathogens, provides a high demand for the discovery of new pharmaceutical drugs to be used clinically to treat these conditions. The Streptomyces genus accounts to produce 39% of all microbial metabolites currently approved for human health, indicating its potential as an important species to study for antimicrobial and anticancer agents. The long linear genome of Streptomyces contains specialized sequences known as …
Occurrence Of Pulmonary Arteritis With Lungworm Infections In Gray Seals From New England, 2013-2020, Jillian R. Broadhurst, Inga Sidor Dvm, Ms, Dacvp
Occurrence Of Pulmonary Arteritis With Lungworm Infections In Gray Seals From New England, 2013-2020, Jillian R. Broadhurst, Inga Sidor Dvm, Ms, Dacvp
Honors Theses and Capstones
Gray seals (Halichoerus grypus) are a common pinniped species in New England coastal waters. Parasitic infection is an important cause of mortality for this species, and lungworm species are frequently implicated in cases of respiratory infection, especially in pups and weanling seals. The most common of these is Otostrongylus circumlitus, a large nematode found in the bronchi and bronchioles of affected seals. The full life cycle is unknown but its presence in lungs and sometimes pulmonary arteries suggests that migration via arterial circulation occurs. Signs and microscopic findings are widely variable; our cases included dyspnea, bloody mucoid …
Sars-Cov-2: An Investigation On Mutagenicity And Its Effects On Infectivity And Mortality, Tyler Elliott Silverwood
Sars-Cov-2: An Investigation On Mutagenicity And Its Effects On Infectivity And Mortality, Tyler Elliott Silverwood
Honors Theses and Capstones
SARS-CoV-2, the etiological agent of the COVID-19 pandemic, has rapidly become a worldwide public health concern. Classified as a betacoronavirus, it is the third human coronavirus (HCoV) to emerge in the 21st century that causes severe disease, alongside SARS-CoV and MERS-CoV. The genome consists of open reading frames encoding accessory proteins and four structural proteins, including the spike protein which is a key determinant of host cell tropism. Mutations within the genome, particularly the spike gene, have been linked in-vitro to increased binding affinity to the human receptor angiotensin-converting enzyme 2 (hACE2), increased fitness in human hosts, and immune evasion. …
Tick-Borne Infections In New Hampshire: An Evaluation Of The Diagnostic Process In A Local Patient Population, Katherine Anderson
Tick-Borne Infections In New Hampshire: An Evaluation Of The Diagnostic Process In A Local Patient Population, Katherine Anderson
Honors Theses and Capstones
Overall, approximately 95 percent of reported cases of vector-borne disease were associated with ticks, making these the most medically important group of arthropods in the United States.1 Despite the prevalence of tick-borne infections, the process for the diagnosis of this condition is not well studied. This study aims to analyze data from a pool of 100 patients who underwent testing for tick-borne disease in the same institution in Dover, New Hampshire during the most recent peak tick season of 2019. Information utilized in this study included: patient age, sex, location of testing (inpatient versus outpatient), diagnostic testing methods used …
Norepinephrine Involvement In The Intermittent Swim Stress-Induced Deficit In Spatial Learning And Memory, Emily Elgert
Norepinephrine Involvement In The Intermittent Swim Stress-Induced Deficit In Spatial Learning And Memory, Emily Elgert
Honors Theses and Capstones
Learning and memory impairments are often caused by stress disorders including depression. The present study investigated the involvement of norepinephrine in the swim stress-induced deficits of spatial learning and memory. Exposure to intermittent swim stress (ISS) followed by learning and memory tests in the Morris water maze (MWM) were used to investigate this relationship. The ISS paradigm consists of intermittent exposure to cold water, producing stress responses in rats. Reboxetine, a norepinephrine selective reuptake inhibitor (NSRI), was employed to investigate whether this compound reverses the ISS-induced deficit. In other words, rats exposed to the ISS, were hypothesized to experience impaired …
Research Experience Outside The Lab, Loreen Fournier
Research Experience Outside The Lab, Loreen Fournier
Inquiry Journal 2007
No abstract provided.
Historical Development Of The Linear Nonthreshold Dose-Response Model As Applied To Radiation, Ronald L. Kathren
Historical Development Of The Linear Nonthreshold Dose-Response Model As Applied To Radiation, Ronald L. Kathren
The University of New Hampshire Law Review
[Excerpt] "Despite the nearly universal adoption of the linear nonthreshold dose response model (LNT) as the primary basis for radiation protection standards for the past half century, the LNT remains highly controversial and a contentious topic of discussion among health physicists, radiation biologists, and other radiological scientists. Indeed, it has been pointed out that the LNT has assumed the status of a paradigm, synonymous with an ideal, standard, or paragon or perhaps to some, a sacred cow. Reduced to its very basics, the LNT postulates that every increment of ionizing radiation dose, however small, carries with it a commensurate increase …
Workplace Pollution: Nuclear Safety, Ethics, And The Exploitation--Avoidance Argument, Kristin Shrader-Frechette
Workplace Pollution: Nuclear Safety, Ethics, And The Exploitation--Avoidance Argument, Kristin Shrader-Frechette
RISK: Health, Safety & Environment (1990-2002)
The author reviews evidence of poor worker health and safety practices in United States Department of Energy nuclear facilities in contending that less protective standards for workplace hazards constitute an environmental injustice not rectified by a hazard pay premium.
Over A Decade Of Comparative Risk Analysis: A Review Of The Human Health Rankings, David M. Konisky
Over A Decade Of Comparative Risk Analysis: A Review Of The Human Health Rankings, David M. Konisky
RISK: Health, Safety & Environment (1990-2002)
The author reviews a method for undertaking a cross-project comparison of comparative risk analyses to understand which environmental problem areas have been cited most as often posing the severest risks.
Review Of: Dangerous Places: Health, Safety, And Archaeology (David A. Poirer & Kenneth L. Feder Eds.), Natalie Duval
Review Of: Dangerous Places: Health, Safety, And Archaeology (David A. Poirer & Kenneth L. Feder Eds.), Natalie Duval
RISK: Health, Safety & Environment (1990-2002)
Review of the book: Dangerous Places: Health, Safety, and Archaeology (David A. Poirier& Kenneth L. Feder eds., Bergin & Garvey, Greenwood Publishing Group, Inc. 2001). Introduction, bibliographic references, index. ISBN0-89789-632-7 [264 pp. $65.00. Cloth, 88 Post Road West, P.O. Box5007, Westport, CT 06881-5007.
Review Of: Health And Disease In Human History (Robert I. Rotberg Ed.), Terry Cromwell
Review Of: Health And Disease In Human History (Robert I. Rotberg Ed.), Terry Cromwell
RISK: Health, Safety & Environment (1990-2002)
Review of the book: Health and Disease in Human History: A Journal of Interdisciplinary History Reader (Robert I. Rotberg ed., MIT Press 2000). ISBN 0- 262-18207-6 [345 pp. $25.00 Paper, 5 Cambridge Street, Cambridge, MA 02142].
Media Coverage Of Epa's Draft Dioxin Reassessment Report, Sharon M. Friedman, Megan A. Fitzpatrick, Brenda P. Egolf
Media Coverage Of Epa's Draft Dioxin Reassessment Report, Sharon M. Friedman, Megan A. Fitzpatrick, Brenda P. Egolf
RISK: Health, Safety & Environment (1990-2002)
Using content analysis, the authors examine the utility of news media in democratic decision making.
Review Of: Elizabeth M. Whelan, Toxic Terror: The Truth Behind The Cancer Scares, Sarah Redfield
Review Of: Elizabeth M. Whelan, Toxic Terror: The Truth Behind The Cancer Scares, Sarah Redfield
RISK: Health, Safety & Environment (1990-2002)
Review of: Elizabeth M. Whelan, Toxic Terror: The Truth Behind the Cancer Scares (Prometheus Books 1993). Acknowledgements, appendix, figures, foreword by Norman F. Borlaug, index, notes tables. LC 92-34154; ISBN 0-87975-788-4. [476 pp. Cloth $26.95. 59 John Glenn Drive, Buffalo NY 14228-2197.]
Coping With The Risk Of Cancer In Children Living Near Power Lines, Eileen N. Abt
Coping With The Risk Of Cancer In Children Living Near Power Lines, Eileen N. Abt
RISK: Health, Safety & Environment (1990-2002)
Ms. Abt briefly summarizes evidence linking power lines with a possible increase in risk of childhood cancer. She also recounts how, although many experts remain skeptical of causality, public fears, whether or not warranted, have themselves created serious problems. Finally, she proposes ways to address those problems.
Review Of: National Research Council, Issues In Risk Assessment, Diane M. Albert
Review Of: National Research Council, Issues In Risk Assessment, Diane M. Albert
RISK: Health, Safety & Environment (1990-2002)
Review of: National Research Council, Issues in Risk Assessment (National Academy Press). Appendices, executive summary, figures, preface, references, tables. LC 92-61838; ISBN 0-309-04786-2. [374 pp. Paper $37.50 - S&H, $4 for first and $0.50 for each additional copy. 2101 Constitution Avenue, NW, Washington DC 20418.]
Review Of: M. Stuart Madden, Toxic Torts Deskbook, Laura Marron
Review Of: M. Stuart Madden, Toxic Torts Deskbook, Laura Marron
RISK: Health, Safety & Environment (1990-2002)
M. Stuart Madden, Toxic Torts Deskbook (Lewis Publishers 1992). Acknowledgements, case index, general index, notes, preface. LC 91-48238; ISBN 0- 87371-508-X. [230 pp. Cloth $69.95 domestic, $84.00 elsewhere. 2000 Corporate Boulevard, NW, Boca Raton FL 33431.]Review of: