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Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Mechanisms Of Condition-Specific Regulation Of Mrna Stability By Puf Proteins: From Yeast To Humans, Joseph Russo
Mechanisms Of Condition-Specific Regulation Of Mrna Stability By Puf Proteins: From Yeast To Humans, Joseph Russo
Dissertations
RNA binding proteins regulate mRNA decay and translation, two key steps in the control of gene expression in cells. Controlling mRNA metabolism allows cells to respond rapidly to altering conditions by utilizing already available mRNA, bypassing the wait for newly transcribed mRNA. The Puf family of RNA binding proteins bind specific mRNAs through interactions with sequences located in the 3’ untranslated region (UTR). Puf proteins are conserved throughout eukaryotes and have diverse roles including stem cell maintenance, neuronal development, stress response and organelle biogenesis. In Saccharomyces cerevisiae, Puf proteins are conditionally regulated in response to the cells metabolic. Specifically, in …
Elucidation Of The Role Of Auxin-Input Pathways In Auxin Homeostasis., Gretchen Spiess
Elucidation Of The Role Of Auxin-Input Pathways In Auxin Homeostasis., Gretchen Spiess
Dissertations
Auxin is a phytohormone involved in cell elongation and division. Levels of indole-3-acetic acid (IAA), the most abundant auxin, are tightly regulated through biosynthesis, degradation, sequestration, and transport. Sequestration of IAA occurs in reversible processes by adding amino acids, polyol or simple alcohols, or sugars, forming IAA conjugates, or via a two-carbon elongation forming indole-3-butyric acid (IBA). These forms of auxin have decreased activity and are located in multiple organelles. Using a combination of molecular and genetic tools, I examined how these storage forms are working together to contribute to overall IAA levels and IAA response in both the model …
Community Organization Of Avian Malaria Parasites In Lowland Amazonia: Prevalence, Diversity, And Specialization In A Local Assemblage, Linda Maria Elenor Svensson
Community Organization Of Avian Malaria Parasites In Lowland Amazonia: Prevalence, Diversity, And Specialization In A Local Assemblage, Linda Maria Elenor Svensson
Dissertations
I characterized a lowland Amazonian assemblage of haemosporidian (“malaria”) parasites (Haemoproteus and Plasmodium) of understory birds by analyzing variation in prevalence (proportion of infected host individuals) among years and host species, documenting diversity of haemosporidian evolutionary lineages, and quantifying host specialization. Using standard molecular methods to screen for haemosporidia in 2488 individual birds from 104 species in the Tiputini Biodiversity Station, Ecuador, I found 21.7% to be infected. Prevalence ranged significantly among years and host species. Forty-five putative evolutionary lineages of haemosporidia were identified, by sequencing part of the cytochrome b (cyt b) gene. Based on a comparative analysis, among …