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Articles 1 - 8 of 8
Full-Text Articles in Life Sciences
Reactive Chemistries For Protein Labeling, Degradation, And Stimuli Responsive Delivery, Myrat Kurbanov
Reactive Chemistries For Protein Labeling, Degradation, And Stimuli Responsive Delivery, Myrat Kurbanov
Doctoral Dissertations
Reactive chemistries for protein chemical modification play an instrumental role in chemical biology, proteomics, and therapeutics. Depending on the application, the selectivity of these modifications can range from precise modification of an amino acid sequence by genetic manipulation of protein expression machinery to a stochastic modification of lysine residues on the protein surface. Ligand-Directed (LD) chemistry is one of the few methods for targeted modification of endogenous proteins without genetic engineering. However, current LD strategies are limited by stringent amino acid selectivity. To bridge this gap, this thesis focuses on the development of highly reactive LD Triggerable Michael Acceptors (LD-TMAcs) …
Improvement Of Solubility, Stability, And Bioaccessibility Of Curcumin Using Colloidal Delivery Systems, Bingjing Zheng
Improvement Of Solubility, Stability, And Bioaccessibility Of Curcumin Using Colloidal Delivery Systems, Bingjing Zheng
Doctoral Dissertations
Curcumin is a yellow-orange crystalline substance found in certain foods (turmeric) that is claimed to exhibit a broad range of biological activities. Its application as a nutraceutical in functional foods and beverages is often limited by its relatively low solubility in aqueous media, its chemical instability, and its low bioavailability. Recent research suggests that colloidal delivery systems can overcome these hurdles and improve the efficacy and commercial value of curcumin in the food, supplement, and pharmaceutical fields. The purpose of this research was to develop colloidal delivery systems to improve the application of curcumin as a nutraceutical in foods. First, …
Depolymerizable And Dissipative Chemical Systems: Role In Material Synthesis And Applications, Vikash Kumar
Depolymerizable And Dissipative Chemical Systems: Role In Material Synthesis And Applications, Vikash Kumar
Doctoral Dissertations
Biomimetic systems which can show a functional response when treated with external stimuli are advantageous in applications such as self-healing, drug delivery, diagnostic and sensing. Depolymerizable and dissipative chemical systems are ideal tools to synthesize biomimetic systems that mimic nature. While there is abundance of synthetic chemistry tools to design depolymerizable systems, there is a lack of synthetic and formulation methodologies for developing useful materials from them. Majority of this thesis is directed towards narrowing that gap in knowledge, by utilizing depolymerizable systems to synthesize useful materials such as hydrogel and polyelectrolyte complexes for applications including self-healing, drug delivery and …
Development Of Colloids-Based Food Delivery Systems To Enhance The Beneficial Effects Of Nutraceuticals For Human Health, Zipei Zhang
Doctoral Dissertations
In current studies, hydrogel particles were formed by polysaccharides (i.e., alginate or pectin) and protein (i.e., casein or gelatin) through complex coacervation. Our results indicated that the encapsulation of protein or polyunsaturated lipid droplets nanoparticles within the hydrogel particles could improve their chemical or physical stability during storage. The lipid droplets encapsulated within the hydrogel particles could be released under simulated oral conditions, which was triggered by a pH or temperature change. The current study further fabricated the hydrogel particles (beads) using alginate or carrageenan based on an injection-gelation method. We found carrageenan beads had a relatively fragile structure that …
Structure-Property Relationships Of Polymer Films And Hydrogels To Control Bacterial Adhesion, Kristopher W. Kolewe
Structure-Property Relationships Of Polymer Films And Hydrogels To Control Bacterial Adhesion, Kristopher W. Kolewe
Doctoral Dissertations
The emergence and spread of antibiotic resistance across microbial species necessitates the need for alternative approaches to mitigate the risk of infection without relying on commercial antibiotics. Biofilm-related infections are a class of notoriously difficult to treat healthcare-associated infections that frequently develop on the surface of implanted medical devices. As biofilm formation is a surface-associated phenomenon, understanding how the intrinsic properties of materials affect bacterial adhesion enables the development of structure-property relationships that can guide the future design of infection-resistant materials. Despite lacking visual, auditory, and olfactory perception, bacteria still manage to sense and attach to surfaces. Previously, it has …
Vitreous Gel Physics, Svetlana Morozova
Vitreous Gel Physics, Svetlana Morozova
Doctoral Dissertations
The transparent vitreous, which fills the posterior cavity of the eye, is incredibly engineered. The charged polyelectrolyte hyaluronic acid (HA) network swells to maintain the pressure in the eye, while stiff collagen type II bundles help absorb any external mechanical shock. Our investigations have contributed to a few key developments related to the physical properties of the vitreous: (1) The stiff collagen network that supports the soft gel network is self-assembled from single triple-helix collagen proteins. Electrostatic interactions drive this assembly, such that the size and concentration are optimized at physiological salt concentrations. The width of the assemblies remarkably changes …
Bioengineered Platforms To Study Carcinoma Cell Response To Drug Treatment, Thuy V. Nguyen
Bioengineered Platforms To Study Carcinoma Cell Response To Drug Treatment, Thuy V. Nguyen
Doctoral Dissertations
The tumor extracellular matrix (ECM) plays an important role in facilitating tumor growth and mediating tumor cells' resistance to drugs. However, during drug development, potential chemotherapeutics are screened in plastic plates, which lack relevant ECM physicochemical cues. In order to improve drug development process, this dissertation includes the development of relevant 2D and 3D biomaterial systems that can be used to study carcinoma cell response to drug treatment. A novel poly(ethylene glycol)-phosphorylcholine (PEG-PC) high-throughput biomaterial platform was developed to study how the ECM mechanochemical properties affect cancer cells' response to drug. The PEG-PC biomaterial is optically transparent, has a mechanical …
Mimicking The Arterial Microenvironment With Peg-Pc To Investigate The Roles Of Physicochemical Stimuli In Smc Phenotype And Behavior, William G. Herrick
Mimicking The Arterial Microenvironment With Peg-Pc To Investigate The Roles Of Physicochemical Stimuli In Smc Phenotype And Behavior, William G. Herrick
Doctoral Dissertations
The goal of this dissertation was to parse the roles of physical, mechanical and chemical cues in the phenotype plasticity of smooth muscle cells (SMCs) in atherosclerosis. We first developed and characterized a novel synthetic hydrogel with desirable traits for studying mechanotransduction in vitro. This hydrogel, PEG-PC, is a co-polymer of poly(ethylene glycol) and phosphorylcholine with an incredible range of Young’s moduli (~1 kPa - 9 MPa) that enables reproduction of nearly any tissue stiffness, exceptional optical and anti-fouling properties, and support for covalent attachment of extracellular matrix (ECM) proteins. To our knowledge, this combination of mechanical range, low …