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Bioenergetic Mechanisms Of Age-Related Differences In Muscle Fatigue, Liam F. Fitzgerald

Doctoral Dissertations

Muscle fatigue is defined as the reduced capacity to produce torque or power in response to contractile activity. Previous work has observed greater fatigue in older than young adults in response to high-velocity contractions, but similar fatigue with age in response to moderate-velocity contractions. The mechanisms for these age-related differences is not clear. One potential explanation is a greater accumulation of putative agents of fatigue (e.g., Pi, H₂PO₄^-, and H⁺) in older than young muscle during high- but not moderate-velocity contractions. Older muscle may accumulate these metabolites to greater extent because of deficits …