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Full-Text Articles in Life Sciences
Development Of Nanoemulsion-Based Delivery Systems For Evaluation Of Triglycerides Bioactivity In Caernohabditis Elegans, Jose D. Colmenares
Development Of Nanoemulsion-Based Delivery Systems For Evaluation Of Triglycerides Bioactivity In Caernohabditis Elegans, Jose D. Colmenares
Masters Theses
Digestion and absorption of bioactive free fatty acids have been studied using the nematode Caernohabditis elegans (C. elegans). However, fatty acids mostly occur in foods in the form of triglycerides, which are highly hydrophobic molecules with low water-solubility, thereby making it difficult to study the fate of ingested fatty acids in C. elegans. The purpose of this research was to develop a method to deliver hydrophobic bioactives, including triglycerides, into C. elegans. Nanoemulsions containing triglyceride nanoparticles were prepared by sonication, and nanoparticle ingestion was confirmed by optical and confocal microscopy, and quantified by spectrometry. Changes in fatty …
Fabrication, Characterization And Biological Fate Of Phytochemical Delivery System, Jingjing Chen
Fabrication, Characterization And Biological Fate Of Phytochemical Delivery System, Jingjing Chen
Doctoral Dissertations
Polymethoxyflvones (PMFs) are a group compounds with promising cancer preventing activities and many other health benefits. There's a growing interest in fabricating delivery systems for PMFs as well as other phytochemicals due to their low water solubility. Firstly, we use nanoemulsion delivery system to encapsulate β-carotene. Sonication assisted method was developed to dissolve β-carotene to ensure minimum degradation. Powdered nanoemulsion was obtained after spray dry and freeze dry. Sample obtained after freeze dry showed better physiochemical characteristics. Then we use protein nanoparticle delivery system to encapsulate PMFS. The nanoparticle delivery system was fabricated by mixing the aqueous phase …