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Articles 1 - 4 of 4
Full-Text Articles in Life Sciences
Anti-Obesity Effects Of Morus Alba L. And Aronia Melanocarpa In A High-Fat Diet-Induced Obese C57bl/6j Mouse Model, Na-Yeon Kim, Shalom Sara Thomas, Dae-Il Hwang, Ji-Hye Lee, Kyung-Ah Kim, Youn-Soo Cha
Anti-Obesity Effects Of Morus Alba L. And Aronia Melanocarpa In A High-Fat Diet-Induced Obese C57bl/6j Mouse Model, Na-Yeon Kim, Shalom Sara Thomas, Dae-Il Hwang, Ji-Hye Lee, Kyung-Ah Kim, Youn-Soo Cha
Nutrition Department Faculty Publication Series
The present study investigated the synergic effect of extracts of Morus alba (MA) and Aronia melanocarpa (Michx.) (AR) against high-fat diet induced obesity. Four-week-old male C57BL/6J mice were randomly divided into five groups that were fed for 14 weeks with a normal diet (ND), high-fat diet (HD), HD with M. alba 400 mg/kg body weight (MA), HD with A. melanocarpa 400 mg/kg body weight (AR), or HD with a mixture (1:1, v/v) of M. alba and A. melanocarpa (400 mg/kg) (MA + AR). Treatment with MA, AR, and MA + AR for 14 weeks reduced high fat diet-induced weight gain …
The Thermogenic Characteristics Of Adipocytes Are Dependent On The Regulation Of Iron Homeostasis, Jin-Seon Yook, Mikyoung You, Yongeun Kim, Mi Zhou, Zhenhua Liu, Young-Cheul Kim, Jaekwon Lee, Soonkyu Chung
The Thermogenic Characteristics Of Adipocytes Are Dependent On The Regulation Of Iron Homeostasis, Jin-Seon Yook, Mikyoung You, Yongeun Kim, Mi Zhou, Zhenhua Liu, Young-Cheul Kim, Jaekwon Lee, Soonkyu Chung
Nutrition Department Faculty Publication Series
The development of thermogenic adipocytes concurs with mitochondrial biogenesis, an iron-dependent pathway. Iron regulatory proteins (IRP) 1 and 2 are RNA-binding proteins that regulate intracellular iron homeostasis. IRPs bind to the iron-response element (IRE) of their target mRNAs, balancing iron uptake and deposition at the posttranscriptional levels. However, IRP/IRE-dependent iron regulation in adipocytes is largely unknown. We hypothesized that iron demands are higher in brown/beige adipocytes than white adipocytes to maintain the thermogenic mitochondrial capacity. To test this hypothesis, we investigated the IRP/IRE regulatory system in different depots of adipose tissue. Our results revealed that 1) IRP/IRE interaction was increased …
Dietary Patterns And Their Association With Hypertension Among Pakistani Urban Adults, Nilofer F. Safdar, Elizabeth Bertone-Johnson, Lorraine Cordeiro, Tazeen H. Jafar, Nancy L. Cohen
Dietary Patterns And Their Association With Hypertension Among Pakistani Urban Adults, Nilofer F. Safdar, Elizabeth Bertone-Johnson, Lorraine Cordeiro, Tazeen H. Jafar, Nancy L. Cohen
Nutrition Department Faculty Publication Series
Hypertension is one of the most common chronic diseases affecting more than 25% of adults worldwide. In Pakistan, 33% of the adult population suffers from hypertension. Numerous epidemiological studies have demonstrated the critical role of dietary patterns in the causation, prevention and management of hypertension. There’s a dearth of evidence from South Asia in this regard. The present study aimed to identify the association between dietary patterns and hypertension among 4304 low income urban adults who participated in the Control of Blood Pressure and Risk Attenuation (COBRA) study in Karachi, Pakistan. Dietary information was collected by a 33- item food …
Dietary Patterns Of Pakistani Adults And Their Associations With Sociodemographic, Anthropometric And Life-Style Factors, Nilofer Safdar, Elizabeth Bertone-Johnson, Lorraine Cordeiro, Tazeen Jafar, Nancy Cohen
Dietary Patterns Of Pakistani Adults And Their Associations With Sociodemographic, Anthropometric And Life-Style Factors, Nilofer Safdar, Elizabeth Bertone-Johnson, Lorraine Cordeiro, Tazeen Jafar, Nancy Cohen
Nutrition Department Faculty Publication Series
Dietary pattern analysis is an epidemiological method designed to consider the complexity of food preferences and diet patterns of populations. Few studies from South Asia have used this methodology to describe population food intake. Our objective was to identify dietary patterns and understand their associations with sociodemographic, anthropometric and life-style factors among low-income Pakistani urban adults. Dietary information was collected by a thirty-three-item FFQ and dietary patterns were derived by principal component analyses in 5491 subjects enrolled in the Control of Blood Pressure and Risk Attenuation (COBRA) study. Three dietary patterns were identified: a fat and sweet pattern characterised by …