Life Sciences Commons^™

Pericyte Nf-Κb Activation Enhances Endothelial Cell Proliferation And Proangiogenic Cytokine Secretion In Vitro, Katherine E. Labarbera, Robert D. Hyldahl, Kevin S. O'Fallon, Priscilla M. Clarkson, Sarah Witkowski

Kinesiology Department Faculty Publication Series

Pericytes are skeletal muscle resident, multipotent stem cells that are localized to the microvasculature. In vivo, studies have shown that they respond to damage through activation of nuclear-factor kappa-B (NF-κB), but the downstream effects of NF-κB activation on endothelial cell proliferation and cell–cell signaling during repair remain unknown. The purpose of this study was to examine pericyte NF-κB activation in a model of skeletal muscle damage; and use genetic manipulation to study the effects of changes in pericyte NF-κB activation on endothelial cell proliferation and cytokine secretion. We utilized scratch injury to …