Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Regulation And Action Of Skp2 And Rhoa In Cell And Tumor Models: Investigation Into The Molecular Mechanisms Responsible For The Aggressive Phenotype Of Triplenegative Breast Cancer, Katrina D. Fagan-Solis
Regulation And Action Of Skp2 And Rhoa In Cell And Tumor Models: Investigation Into The Molecular Mechanisms Responsible For The Aggressive Phenotype Of Triplenegative Breast Cancer, Katrina D. Fagan-Solis
Open Access Dissertations
Breast cancer tops the list of new cancer cases and is predicted to be the second leading cause of cancer deaths in women in 2012. The primary objective of the present study was to provide insights into the molecular mechanisms underlying the aggressive growth and metastasis of triple-negative and basal-like breast cancers. To study increased growth and invasive behavior in triple-negative and basal-like breast cancers we utilize both an interesting and relevant cell culture model and examination of human tissue.
In this study, we use the Tamoxifen-selected, MCF-7 derivative, TMX2-28 breast cancer cell line. TMX2-28 cells are triple-negative in that …