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Articles 1 - 11 of 11
Full-Text Articles in Life Sciences
Lipid-Coated Gold Nanoparticle As A Biosensor For Lipid-Protein Interactions, Yuheng Cai
Lipid-Coated Gold Nanoparticle As A Biosensor For Lipid-Protein Interactions, Yuheng Cai
Electronic Theses and Dissertations
Gold nanoparticles have been intensively studied for their unique optical features. Due to surface plasmon resonance phenomenon, gold nanoparticles can respond to the refractive index change of the environment near the particles. This phenomenon gives gold nanoparticles the potential to become biosensors that detect the biological interactions at or near the particles. In this work, gold nanospheres were coated with phosphatidylcholine as the substrate for lipoxygenase. It is demonstrated, in our work, that lipid coated gold nanospheres can be used to detect the activity of lipoxygenase and provide more information of this reaction than common assays, like conjugated diene assay …
Gene Expression In The Choanoderm, Jesús Federico Peña
Gene Expression In The Choanoderm, Jesús Federico Peña
Electronic Theses and Dissertations
The body plan of sponges (phylum Porifera) is an outlier among modern animals and is thought to have special evolutionary significance. Sponges lack muscles, nerves and a gut. Instead, they are composed of few cell types and simple tissues that function to pump water through an internal canal network where bacterial prey are filtered by a specialized tissue called the choanoderm. The choanoderm is composed of cells with striking similarity to choanoflagellates, the unicellular relatives of animals. Thus, the traditional view is that the sponge choanoderm is a useful model of the first animal epithelial tissues. Using the freshwater sponge …
Rab8 Directs Tubulation And Furrow Ingression During Epithelial Formation In Drosophila Melanogaster, Lauren Mackenzie Mavor
Rab8 Directs Tubulation And Furrow Ingression During Epithelial Formation In Drosophila Melanogaster, Lauren Mackenzie Mavor
Electronic Theses and Dissertations
One of the most fundamental changes in cell morphology is the formation of a plasma membrane furrow. The Drosophila embryo undergoes several cycles of rapid furrow ingression during early development, which culminates in the formation of an epithelial sheet. Previous studies have demonstrated the requirement for intracellular trafficking pathways in furrow ingression; however, the pathways that link compartmental behaviors with cortical furrow ingression events have remained unclear. This research shows that Rab8, a small GTPase associated with late exocytic trafficking events, demonstrates striking dynamic behaviors in vivo; transitioning from punctate structures to a stable association with the cortex during …
Species Preference Of Viral Deubiquitinating Proteases Toward Isg15 Through Structural And Enzymatic Characterization, Michelle Kay Deaton
Species Preference Of Viral Deubiquitinating Proteases Toward Isg15 Through Structural And Enzymatic Characterization, Michelle Kay Deaton
Electronic Theses and Dissertations
Proteases from the Ovarian Tumor domain (OTU) superfamily of deubiquitinating enzymes (DUBs) are expressed by a range of RNA viruses. Viral OTUs (vOTUs) are found in nairoviruses such as Crimean Congo Hemorrhagic Fever virus (CCHFV), Nairobi sheep disease virus (NSDV), the Erve virus (ERVEV), and the Dugbe virus (DUGV), as well as in the areterivirus Porcine Reproductive and Respiratory Syndrome virus (PRRSV), among others. vOTUs, which interfere with host innate immune response through editing of host Ub and Ub-like molecules such as interferon stimulated gene 15 (ISG15), have been identified as a potential virulence factor through their role in evading …
Empowering Students To Care: An Edible Garden And Farm Education Approach, Shannon C. Mcqueen
Empowering Students To Care: An Edible Garden And Farm Education Approach, Shannon C. Mcqueen
Electronic Theses and Dissertations
Through this qualitative study, I want to add to the theoretical conversation about garden and farm education in schools and offer a starting point for a conversation surrounding care and gardening/farming in schools. The purpose of this study is to understand how teachers and students demonstrate care while implementing a garden and farm curriculum. Data collection included 15 participant interviews from students, staff, administrators, and school officials from a large public school district implementing garden and farm education lessons and observations of educators, farmers, and farm interns interacting with and instructing students in a weeklong Farm Camp environment. I utilized …
Regulation Of Synaptogenesis By The Mirna Pathway And Fmr/P Bodies, Jacqueline Rochelle Furlong
Regulation Of Synaptogenesis By The Mirna Pathway And Fmr/P Bodies, Jacqueline Rochelle Furlong
Electronic Theses and Dissertations
Post-transcriptional regulation of mRNA is facilitated by different mechanisms, such as microRNA (miRNA) induced gene silencing or fragile X mental retardation protein (FMRP) mediated repression either independent of or acting through cytoplasmic RNA Processing bodies (P bodies). DPTP99A, Lar, and Wg have known functions during synaptogenesis and may be targets of miR-8. Here, we provide evidence that miR-8 regulates DPTP99A in vitro. Non-endogenous miR-8 expressed using an UAS driver regulates Lar. Endogenous miR-8 may regulate DPTP99A in vivo. Here we show that FMRP is capable of colocalizing with the P body components: DCP1, HPat, and Me31B, but not …
Phytoremediation Of Metal Contamination Using Salix (Willows), Gordon J. Kersten
Phytoremediation Of Metal Contamination Using Salix (Willows), Gordon J. Kersten
Electronic Theses and Dissertations
Abandoned hardrock mines and the resulting Acid Mine Drainage (AMD) are a source of vast, environmental degradation that are toxic threats to plants, animals, and humans. Cadmium (Cd) and lead (Pb) are metal contaminants often found in AMD. In my mine outwash water samples, cadmium and lead concentrations were 19 and 160 times greater than concentrations in control waterways, and 300 and 40 times greater than EPA Aquatic Life Use water quality standards, respectively. I tested the phytoremediation characteristics of three montane willows native to the Rocky Mountains: Salix drummondiana, S. monticola, and S. planifolia. I tested …
Towards Closed-Loop Deep Brain Stimulation: Behavior Recognition From Human Stn, Soroush Niketeghad
Towards Closed-Loop Deep Brain Stimulation: Behavior Recognition From Human Stn, Soroush Niketeghad
Electronic Theses and Dissertations
Deep brain stimulation (DBS) provides significant therapeutic benefit for movement disorders such as Parkinson’s disease (PD). Current DBS devices lack real-time feedback (thus are open loop) and stimulation parameters are adjusted during scheduled visits with a clinician. A closed-loop DBS system may reduce power consumption and side effects by adjusting stimulation parameters based on patient’s behavior. Thus behavior detection is a major step in designing such systems. Various physiological signals can be used to recognize the behaviors. Subthalamic Nucleus (STN) Local field Potential (LFP) is a great candidate signal for the neural feedback, because it can be recorded from the …
Is Colorado Buddhism Green? A Study Of The Interaction Of Buddhist Practice With Environmental Concerns, Mengye Liu
Is Colorado Buddhism Green? A Study Of The Interaction Of Buddhist Practice With Environmental Concerns, Mengye Liu
Electronic Theses and Dissertations
The human community is paying more attention to our growing environmental crisis. Religious beliefs are often proposed as effective ways to address environmental ethics. It is often supposed that Buddhism is a "green" religion because of its intimate associations with nature. My research focuses on whether or not Buddhism in Colorado influences Buddhist practitioners' environmental awareness by identifying and evaluating Buddhist ecological attitudes and values. My research questions include: (1) what aspects of Buddhist practice refer to the elements of natural environment, (2) do Buddhist practitioners profess different attitudes and behaviors than non-Buddhist practitioners, and (3) If so, how does …
The Role Of Cognition In Sexual Signals And Mate Choice Decisions, Ross Minter
The Role Of Cognition In Sexual Signals And Mate Choice Decisions, Ross Minter
Electronic Theses and Dissertations
Cognitive ability varies dramatically among individuals, yet the manner in which this variation affects reproduction has rarely been investigated. Here, we asked 1) whether male sexual signals reflect cognitive ability and whether females prefer males with superior cognitive abilities, and 2) whether female cognition affects male and female mating decisions? We addressed these questions in a mutual mate choice system, threespine sticklebacks (Gasterosteus aculeatus). We tested cognitive performance by presenting the males and females with a novel task (a barrier to food) to evaluate problem-solving abilities and learning. We found that males that problem solve have elaborate sexual …
The Effects Of Molecular Chaperones On Tau Fibril Assembly, Ahmed Omran
The Effects Of Molecular Chaperones On Tau Fibril Assembly, Ahmed Omran
Electronic Theses and Dissertations
The accumulation of microtubule-associated protein tau into fibrillar aggregates is the hallmark of Alzheimer’s disease and other neurodegenerative disorders, collectively referred to as tauopathies. Fibrils can propagate from one cell to the next and spread throughout the brain. However, a study shows that only small aggregates can be taken up by cultured neuronal cells. The mechanisms that lead to the breakage of fibrils into smaller fragments remain unknown. In yeast, the AAA+ chaperone HSP104 processes the reactivation of protein aggregates and is responsible for fragmentation of fibrils. This study focused on investigating the effects of molecular chaperones on tau fibrils …