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The Effects Of Aging And Injury On The Murine Ependymal Barrier And Subventricular Zone, John J. Peters
The Effects Of Aging And Injury On The Murine Ependymal Barrier And Subventricular Zone, John J. Peters
Honors Scholar Theses
Previous research has shown that numerous age-related changes occur in the subventricular zone (SVZ) and diminish the neurogenic output of the region. Here, various age-related changes in the structure of the lateral ventricle, the ependymal barrier, and the SVZ were examined. It was found that the walls of the lateral ventricles move together, adhere, and eventually fuse. This results in a degradation of the SVZ. Other changes associated with aging were found, including ependymal cell stretching, heightened, ependymal repair, changes in CSF flow velocity and dynamics, and altered ependymal cell polarity. These changes may be related to the process of …