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The Possible Enzymatic Differences Between Cattle And Sheep In Their Response To Ergot Alkaloids, Susan M. Cannon, Charles F. Rosenkrans, Ali Moubarak
The Possible Enzymatic Differences Between Cattle And Sheep In Their Response To Ergot Alkaloids, Susan M. Cannon, Charles F. Rosenkrans, Ali Moubarak
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
Ergotamine is an ergot alkaloid associated with fescue toxicosis of livestock who have grazed endophyte-infected fescue. High performance liquid chromatography (HPLC) was used to detect individual or species-specific differences in the metabolism of ergotamine by liver cytochrome P450 of sheep and cattle. Livers were collected from four steers and two sheep. The diet of the steers used in this study consisted of two being fed a grain diet, one steer grazing endophyte-infected fescue, and the final steer grazing endophyte-free fescue. The two lambs were both fed a grain diet. Livers were prepared and examined for the disappearance of ergotamine and …