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Regional Specialization Of The Adult Meninges Supports Different Brain Areas And Alters With Age, Christina Ann Calabrese
Regional Specialization Of The Adult Meninges Supports Different Brain Areas And Alters With Age, Christina Ann Calabrese
Legacy Theses & Dissertations (2009 - 2024)
The meninges comprise three heterogeneous connective tissue coverings, referred to as the dura, arachnoid, and pia mater, which completely envelop the brain and spinal cord. Given the meninges’ vast coverage over the entire CNS and its unique development, I hypothesized that regional leptomeninges (arachnoid and pia mater layers combined) provide specialized support to different brain areas. During development, anterior meninges, overlying the frontal cortex, derive from neural crest cells that are ectodermal in origin. Posterior meninges, overlying the midbrain to the spinal cord, derive from a mesodermal lineage. This difference in lineage and location suggests potential functional differences between the …