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- Botrytis cinerea (3)
- Defense response (3)
- Abiotic stress (2)
- Arabidopsis thaliana (2)
- B. cinerea up-regulated genes (2)
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- Coexpression (2)
- Neurobiology; death associated protein kinase 1; peripheral nerve injury; dorsal root ganglion; pain; regeneration (2)
- TGA transcription factor (2)
- Transcriptome (2)
- ABO blood group (1)
- Al Ain. (1)
- Alfa alfa & Cowpea (1)
- Antibiofilm (1)
- Antimicrobial (1)
- Apoptotic cell death. (1)
- Arabidopsis (1)
- Arbuscular mycorrhizal fungi (1)
- B. cinerea down-regulated genes (1)
- B. cinerea down-regulated genes. (1)
- Biochemical and mineral nutrients. (1)
- Biofilm (1)
- Cancer (1)
- Cell cycle (1)
- Cell viability (1)
- Co-precipitation (1)
- Compatible solutes (1)
- Compositional index (1)
- Crocin (1)
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- Publication
Articles 1 - 15 of 15
Full-Text Articles in Life Sciences
Effects Of Glycine Betaine On Plant Growth And Performance Of Alfalfa (Medicago Sativa L.) & Cowpea (Vigna Unguiculata L. Walp.) Within Water Deficit Conditions, Hanan Kamal Khadouri
Effects Of Glycine Betaine On Plant Growth And Performance Of Alfalfa (Medicago Sativa L.) & Cowpea (Vigna Unguiculata L. Walp.) Within Water Deficit Conditions, Hanan Kamal Khadouri
Theses
Managing water consumption of the crops is one of the strategies which have been adopted locally and worldwide in current trends of sustainable agriculture, in addition to the low level of water resources in UAE because of the rare precipitation, no fresh free flowing water; no rivers, lakes or streams. The present study was objective to evaluate the effects of organic exogenous Glycine Betaine on two forage crops Alfa alfa (Medicago sativa L.) & Cowpea (Vigna unguiculata L. Walp.) within different levels of drought stress. A pot experiment was designed on completely randomized block design (CRBD) with three replicates in …
Virtual Screening Of Phytochemicals For Cancer Therapy, Asma Ahmad Al Haddad
Virtual Screening Of Phytochemicals For Cancer Therapy, Asma Ahmad Al Haddad
Theses
Cancer is one of the leading cause of deaths in the world. Vast majority of contemporary cancer therapies have side effects. Dietary plants and plant-based products have been shown to reduce the severity of the condition with minimal or no side effects. However, the precise molecular interactions that lead to this are largely unknown. In this study, several target proteins in cancer pathways were chosen and a collection of chemical derived from plants, or phytochemicals, were virtually screened in silico using molecular docking techniques. Furthermore, the docking modes were subjected to extended molecular dynamics (MD) simulations. The pharmacokinetic properties of …
Molecular Targets Of Manuka Honey In Human Breast Cancer, Sarah Saif Al Qubaisi
Molecular Targets Of Manuka Honey In Human Breast Cancer, Sarah Saif Al Qubaisi
Theses
The medicinal properties of Manuka honey have been extensively studied, particularly in terms of its wound healing and antimicrobial activities. We have previously demonstrated that Manuka honey also has anti-cancer properties against a variety of cancer cell types in vitro as well as in preclinical cancer models. The cellular targets of the anti-cancer activity of Manuka honey, however, remain unknown. For the present study, we selected the triple negative human breast cancer cell line, MDA-MB-231, to investigate susceptibility to Manuka honey and to identify the potential signaling pathways affected. MDA-MB-231 cancer cells are known to constitutively express activated STAT3 transcription …
Frequency Of Abo, Rhesus Phenotypes And Most Probable Genotypes And The Type Of Rhd Negative Variants Among Uae Nationals In Al Ain District, Mariam Hamad Zaher Saeed Ai Meqbali
Frequency Of Abo, Rhesus Phenotypes And Most Probable Genotypes And The Type Of Rhd Negative Variants Among Uae Nationals In Al Ain District, Mariam Hamad Zaher Saeed Ai Meqbali
Theses
Knowledge of the frequencies and the phenotypes of ABO and rhesus system is very important for blood bank and transfusion services policies. The objective of this study was to determine the frequency of ABO, Rhesus phenotype and most probable genotypes in Al Ain area (UAE). The studied group consisted of 500 locals of both gender from different age groups (17-58 years old). ABO and Rh-hr phenotype reactivity were determined using conventional tube method and gel technology, molecular techniques were also applied. Our study shows the distribution of ABO phenotypes was as follows: 0= 56%, A= 26.2%, B= 14.2% and AB= …
Identification Of Arabidopsis Candidate Genes In Response To Biotic And Abiotic Stresses Using Comparative Microarrays, Salma Omar Al Ameri
Identification Of Arabidopsis Candidate Genes In Response To Biotic And Abiotic Stresses Using Comparative Microarrays, Salma Omar Al Ameri
Theses
Plants have evolved with intricate mechanisms to cope with multiple environmental stresses. To adapt with biotic and abiotic stresses, plant responses involve changes at the cellular and molecular levels. The current study was designed to investigate the effects of combinations of different environmental stresses on the transcriptome level of Arabidopsis thaliana genome using public microarray databases. We investigated the role of cyclopentenones in mediating plant responses to environmental stress through TGA (TGACG motif-binding factor) transcription factor, independently from jasmonic acid. Candidate genes were identified by comparing plants inoculated with Botrytis cinerea or treated with heat, salt or osmotic stress with …
Anti-Colon Cancer Activity Of Origanum Majorana, Nedaa Faisal Al Tamimi
Anti-Colon Cancer Activity Of Origanum Majorana, Nedaa Faisal Al Tamimi
Theses
In the present project, we extend the previous studies of Origanum majorana by evaluating the anti-cancer potential of this plant extract on proliferation of colon cancer. Toward this, we first evaluated the effect of the plant extract on the proliferation and DNA damage, in vitro, of the human colon cancer HT-29 cell line. We also determine the mechanism by which Origanum majorana induced cell death by this extract using biochemical approach. Our results revealed that O. majorana inhibited the growth of HT-29 cells by effecting the cells viability. Further work showed the ability of the extract to cause DNA damage, …
Protein Domain Linker Prediction: A Direction For Detecting Protein – Protein Interactions, Maad Mohammad Hasan Shatnawi
Protein Domain Linker Prediction: A Direction For Detecting Protein – Protein Interactions, Maad Mohammad Hasan Shatnawi
Dissertations
Protein chains are generally long and consist of multiple domains. Domains are the basic of elements of protein structures that can exist, evolve and function independently. The accurate and reliable identification of protein domains and their interactions has very important impacts in several protein research areas. The accurate prediction of protein domains is a fundamental stage in both experimental and computational proteomics. The knowledge is an initial stage of protein tertiary structure prediction which can give insight into the way in which protein works. The knowledge of domains is also useful in classifying the proteins, understanding their structures, functions and …
Trascriptome Analysis Reveals Genes Commonly Induced By Botrytis Cinerea Infection, Cold, Drought And Oxidative Stresses In Arabidopsis Thaliana, Ahmed Dawood Al-Azzawi Al-Azzawi
Trascriptome Analysis Reveals Genes Commonly Induced By Botrytis Cinerea Infection, Cold, Drought And Oxidative Stresses In Arabidopsis Thaliana, Ahmed Dawood Al-Azzawi Al-Azzawi
Theses
Signaling pathways controlling biotic and abiotic stress responses may interact synergistically or antagonistically. To identify the similarities and differences among responses to diverse stresses, we analyzed previously published microarray data on the transcriptomic responses of Arabidopsis thaliana to infection with Botrytis cinerea (a biotic stress), and to cold, drought, and oxidative stresses (abiotic stresses). Our analyses showed that at early stages after B. cinerea inoculation, 1498 genes were up-regulated (B. cinerea up-regulated genes; BUGs) and 1138 genes were down-regulated (B. cinerea down-regulated genes; BDGs). We showed a unique program of gene expression was activated in response each biotic and abiotic …
Transcriptomes Analysis Reveals Genes Commonly Induced By Botrytis Cinerea Infection, Cold, Drought And Oxidative Stresses In Arabidopsis Thaliana, Ahmed Dawood Al-Azzawi
Transcriptomes Analysis Reveals Genes Commonly Induced By Botrytis Cinerea Infection, Cold, Drought And Oxidative Stresses In Arabidopsis Thaliana, Ahmed Dawood Al-Azzawi
Theses
Signaling pathways controlling biotic and abiotic stress responses may interact synergistically or antagonistically. To identify the similarities and differences among responses to diverse stresses, we analyzed previously published microarray data on the transcriptomic responses of Arabidopsis thaliana to infection with Botrytis cinerea (a biotic stresses). Our analyses showed that at least at early stages B. cinerea inoculation, 1498 genes were up-regulated (B. cinerea up-regulated genes; BUGS) and 1138 genes were down-regulated (B. cinerea down-regulated genes; BUGS). We showed a unique program of gene expression was activated in response each biotic and abiotic stress, but that …
Development And Functioning Of Mycorrhizal Root Systems Under Non-Uniform Rootzone Salinity, Asha Christopher
Development And Functioning Of Mycorrhizal Root Systems Under Non-Uniform Rootzone Salinity, Asha Christopher
Dissertations
Arbuscular mycorrhiza are obligate symbionts that live in association with most plant roots. The fungal mycelium extracts nutritional elements from the soil, and supplies these to plants in exchange for plant photoassimilates. The present study investigated the effects of root colonization by arbuscular mycorrhizal fungi on growth and nutrient uptake of tomato (Solanum lycopersicum L.) and Sudan grass (Sorghum bicolor L.) exposed to topsoil salinity through a horizontal split-root set-up. Roots in the upper compartment were exposed to substrate salinity, while lower compartment roots had access to non-saline nutrient solution. Despite roots being well-colonized by mycorrhizal fungi, there was no …
Biofilm Production By Food-Transmitted Bacteria And Their Control By Selected Nanoparticles, Mariam Al Shamsi
Biofilm Production By Food-Transmitted Bacteria And Their Control By Selected Nanoparticles, Mariam Al Shamsi
Dissertations
Biofilm is a population of bacteria attached to any types of surfaces and impeded in a self-produced matrix of extracellular polymeric substances. Biofilm exhibit up to 1000 fold antibiotic increased resistance to a broad range of antimicrobial agents. Several food-transmitted microorganisms are capable of forming biofilms and considered as a major source of contamination, transmission and infection. In the last few decades, nanoparticles has gained a great attention for their potential applications as antimicrobial agents. The aim of this work was to assess the biofilm formation capacity of food-transmitted bacteria under various environmental conditions and to investigate the efficacy of …
Induction Of Anti-Microbial Immune Responses In Severely Immunodeficient Hosts By Ifn-Expressing Salmonella Enterica Serovar Typhimurium Correlates With Efficient Activation Of Macrophage Effectors, Mohammed Achraf Al-Sbiei This
Induction Of Anti-Microbial Immune Responses In Severely Immunodeficient Hosts By Ifn-Expressing Salmonella Enterica Serovar Typhimurium Correlates With Efficient Activation Of Macrophage Effectors, Mohammed Achraf Al-Sbiei This
Theses
Susceptibility to infection by the intracellular bacterial pathogen, Salmonella enterica serovar Typhimurium (S. typhimurium), is controlled by many genes of innate and adaptive immunity. One of the most critical genes is IFN- and mice deficient in IFN- synthesis are highly susceptible to Salmonella. Previously, we demonstrated that mice deficient in MyD88, an adaptor that regulates TLR signaling, are susceptible to Salmonella infection. In the current study, we compared immune responses in mice deficient in IFN- or MyD88 with wild-type controls following infection with an attenuated strain of S. typhimurium (designated BRD509E) or a recombinant derivative engineered to express murine IFN- …
Development Of A Therapeutic Model Of Early Liver Cancer Using Crocin-Coated Magnetite Nanoparticles, Rkia El-Kharrag
Development Of A Therapeutic Model Of Early Liver Cancer Using Crocin-Coated Magnetite Nanoparticles, Rkia El-Kharrag
Dissertations
Hepatocellular carcinoma is one of the most common health problems that is difficult to treat. As a result of the side effects frequently experienced with conventional cancer treatments, there has been a growing interest to develop controlled drug delivery system that can reduce the mortality rate of liver cancer patients and un-harm healthy tissues. Magnetite nanoparticles are potentially important in hepatocellular carcinoma treatment, since they can be used as delivery system. Pure and coated magnetite nanoparticles were synthesized via modified co-precipitation method in air at low temperature. Various reaction parameters and coating materials have been investigated and characterized. Among these …
The Expression Pattern Of Death Associated Protein Kinase1 In Normal Dorsal Root Ganglion Neurons And Following Peripheral Nerve Injury, Maryam Sulaiman Mohammed Al Saadi
The Expression Pattern Of Death Associated Protein Kinase1 In Normal Dorsal Root Ganglion Neurons And Following Peripheral Nerve Injury, Maryam Sulaiman Mohammed Al Saadi
Theses
Death-associated protein kinase 1 (DAPK1) is a calcium/calmodulin (Ca2+/CaM) regulated serine/threonine kinase. An increasing body of evidence supports the significance of DAPK 1 protein in cancer and CNS diseases. The role of DAPK in peripheral nerve regeneration and neuropathic pain remains completely unexplored. The aim of this study is to investigate the expression pattern of DAPK1 along with key pro-and anti-apoptotic cell signaling molecules (p53, Bax, Akt, ERK5, p38) and to verify the possibilities of DAPKI1-NMDA NR2B relationship in dorsal root ganglion neurons (DRG) after 2 hours, 7 days and 14 days following a sciatic nerve injury. Gene …
The Expression Pattern Of Death Associated Protein Kinase1 In Normal Dorsal Root Ganglion Neurons And Following Peripheral Nerve Injury, Maryam Sulaiman Mohammed Al Saadi
The Expression Pattern Of Death Associated Protein Kinase1 In Normal Dorsal Root Ganglion Neurons And Following Peripheral Nerve Injury, Maryam Sulaiman Mohammed Al Saadi
Dissertations
Death-associated protein kinase1 (DAPK1) is a calcium/calmodulin (Ca2+/CaM) regulated serine/threonine kinase. An increasing body of evidence supports the significance of DAPK1 protein in cancer and CNS diseases. The role of DAPK in peripheral nerve regeneration and neuropathic pain remains completely unexplored. The aim of this study is to investigate the expression pattern of DAPK1 along with key proand anti-apoptotic cell signaling molecules (p53, Bax, Akt, ERK5, p38) and to verify the possibilities of DAPK1-NMDA NR2B relationship in dorsal root ganglion neurons (DRG) after 2 hours, 7 days and 14 days following a sciatic nerve injury. Gene expression analysis and immunohistochemistry …