Life Sciences Commons^™

Effect Of Lead On Flexor Muscle Contraction And Photochemically-Induced Platelet Aggregation In Pial Microcirculation Of The Mouse, Amna Hamad Al Dhaheri

Theses

Lead is one of many heavy metal ions that can effectively compete for the binding sites of calcium, block the calcium channels and disturb the ion exchange. As a result, lead would be expected to affect the calcium-mediated cell functions. Muscle contraction and platelet aggregation are two important functions in which Ca²⁺ plays a major role and ultimately are affected by lead. Experiments were carried out to investigate the effect of lead on mouse flexor muscle contraction and on photochemically-induced platelet aggregation in pial microcirculation. A study of an acute exposure (1, 5, 10 and 25 µM) and a …