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Dynamics Of Protofibril Elongation And Association Involved In Aβ42 Peptide Aggregation In Alzheimer's Disease, Preetam Ghosh, Amit Kumar, Bhaswati Datta, Vijayaraghavan Rangachari

Faculty Publications

Background: The aggregates of a protein called, ‘Aβ’ found in brains of Alzheimer’s patients are strongly believed to be the cause for neuronal death and cognitive decline. Among the different forms of Aβ aggregates, smaller aggregates called ‘soluble oligomers’ are increasingly believed to be the primary neurotoxic species responsible for early synaptic dysfunction. Since it is well known that the Aβ aggregation is a nucleation dependant process, it is widely believed that the toxic oligomers are intermediates to fibril formation, or what we call the ‘on-pathway’ products. Modeling of Aβ aggregation has been of intense investigation during the last …