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Full-Text Articles in Life Sciences
Interregulation Between Msaabcr Operon And Ccpe To Determine Staphylococcal Metabolism And Virulence, Erin R. Cox
Interregulation Between Msaabcr Operon And Ccpe To Determine Staphylococcal Metabolism And Virulence, Erin R. Cox
Honors Theses
Staphylococcus aureus is a complex human pathogen that causes problems in both healthcare and community settings. Staphylococcus aureus is a gram-positive, sphere shaped bacterium that usually colonizes in the nasal cavity of healthy individuals. Staphylococcus aureus infections are a growing health concern due to its ability to produce virulence factors, such as pigmentation, protease production, and capsule formation. Two regulators in S. aureus virulence factors are msaABCR, which is a newly characterized operon, and ccpE. In order to determine the interaction between these two regulators in regulating virulence and metabolism in S. aureus, ccpE and ccpE/ …
Study Of The Role Of The Msaabcr Operon In Tricarboxylic Acid Cycle Activity And Persister Cell Formation In Staphylococcus Aureus, Karsen Motter
Study Of The Role Of The Msaabcr Operon In Tricarboxylic Acid Cycle Activity And Persister Cell Formation In Staphylococcus Aureus, Karsen Motter
Honors Theses
Staphylococcus aureus is an important human pathogen that causes wide arrays of infections ranging from minor skin infections to lethal systemic conditions such as infective endocarditis, osteomyelitis, sepsis and pneumonia. These systemic diseases are often difficult to treat due to the presence of persister cells. Persister cells are a phenotypic variant of the bacterial population that exhibit extreme and transient antibiotic tolerance accompanied by a transient halt in growth. Upon cessation of antibiotic treatment, however, persisters resume growth which results in recurrence of infections. This characteristic of persister cells therefore displays high clinical significance. In this study, we show the …
The Effect Of Truncated Complement Constructs On Biofilm Formation, Protease Production, And Pigmentation, Cara L. Cothern
The Effect Of Truncated Complement Constructs On Biofilm Formation, Protease Production, And Pigmentation, Cara L. Cothern
Honors Theses
The msaABCR operon regulates virulence factors in Staphylococcus aureus, a Gram-positive commensal organism that colonizes healthy individuals but can also be a human pathogen. These virulence factors include biofilm development, pigmentation, and extracellular protease production. The operon consists of the msaB gene, which produces a coding transcript, the msaA gene and the msaC gene, which produce noncoding RNAs, and msaR, which produces an antisense RNA. The latter three transcript regions of the operon are referred to as untranslated regions (UTRs) and are essential for the function of the operon, but only msaB encodes a protein. The mechanism of …