Life Sciences Commons^™

Synthesis Of A Glutathione Analogue Using 2-Α-Methyl-Β-Cysteine, Nathan Freeman

Honors Theses

Inhibitors of glutathione reductase (GR) have been synthesized and studied in order to reverse an increasing trend in resistance to common malaria treatments. Analogues of glutathione (GSH) are being synthesized in order to increase resistance to proteolysis, thereby acting as an inhibitor of GR. Through the use of unnatural amino acids, solution-phase synthesis of GSH can be easily performed using modified cysteine (Cys) residues. A modified Cys residue, 2-α-methyl-β-cysteine, has been successfully synthesized, and coupling of this residue with the other required residues of GSH, glycine (Gly) and glutamic acid (Glu), has the potential to be successfully synthesized in good …

The Identification Of Arachnid Species In The Cockscomb Basin Wildlife Sanctuary, Lauren Auer

Honors Theses

Despite the known diversity of arachnids in neotropical ecozones there has been little considerable movement towards creating a collective means for identification of arachnids in Belize. Previous studies on ecotourism indicate positive trends between biodiversity education and conservation concern. This study was conducted to engage in a field-based study of arachnids in the Cockscomb Basin Wildlife Sanctuary to determine the most frequently encountered arachnid species. For this study, four separate locations were surveyed within the Sanctuary: three trail sites and the main camp area. Each site was surveyed during two alternate time periods to account for diurnal and nocturnal species. …

Determining The Diversity Of Wetland Fungi Through Molecular-Based Species Identification, Kimberly Chesteen

Honors Theses

This study used molecular techniques to examine the diversity of fungal species inhabiting leaf and stem litter of the freshwater emergent macrophyte, Typha angustifolia, during decomposition. Because morphological identification of fungal species is frequently inaccurate and underestimates the number of fungal species present, molecular techniques involving rRNA genes such as ITS regions (internal transcribed spacer regions) are used to better determine specific fungal species within a sample. In this study, samples of decaying leaf and stems litter of Typha angustifolia were obtained from Independence Lake, Michigan over the span of a year. DNA from litter samples obtained from the months …

Spiders Of Riparian Communities In The Cockscomb Basin Wildlife Sanctuary, Belize, Megan Chevis

Honors Theses

Currently there is little literature on what arachnids inhabit the tropics of Central America, especially within the country of Belize. This study aimed to find which spider species are found in riparian areas within the Cockscomb Basin Wildlife Sanctuary in central Belize and to distinguish trends among spiders and the microhabitats in which they live. Nocturnal samples were predicted to have greater diversity than diurnal samples at all sites. Pisauridae, Salticidae, and Lycosidae were predicted to be the most common spider families collected. Specimens were collected from three riparian sites located on trails within Cockscomb. Diurnal and nocturnal samples were …

The Effects Of An Informal Science Education Setting On Students’ Attitudes Towards Learning Science, Lauren Finley

Honors Theses

Informal science education is becoming increasingly popular in today’s classrooms, and for this reason, it is important to understand the effects of informal science education on students. In this study, the Children’s Attitude Survey (Wulf, Mayhew, & Finkelstein, 2009) was used to measure the effects of informal science education on students’ attitude toward science. Questionnaires were administered to two sample sets, and results indicated a slight decrease in attitude after participating in an informal science field trip. Continuing research in this area will provide more insight into why these effects were seen, and how informal science education can be best …

Television’S Effects On Speech And Language: The Parent’S Perspective, Hillary Fortenberry

Honors Theses

Purpose: This study focuses on an area seldom studied, the parent’s perception of television’s influence on their speech and language disordered child’s receptive and expressive skills. Understanding the parent’s perspective on specific effects television has on speech and language development can be valuable by providing educators and child caretakers with answers as to why parents allow their children to watch television. With this knowledge, parents can be educated as to what type of programming and to what extent viewing should be allowed for children to gain positive speech and language outcomes from their television viewing experience.

Method: .This study gathered …

The Role Of Midline And Pexin10 In Regulating Drosophila Eye Development, John Forstall

Honors Theses

The Drosophila midline (mid) transcription factor gene encodes a highly conserved invertebrate ortholog of the mammalian Tbx20 gene essential for regulating the development of diverse tissues including the central nervous system (CNS), epidermis and heart. Decreasing mid transcript levels within larval eye discs using RNAi (mid- RNAi) results in poorly organized IPCs and in adult eyes, interommatidal bristles derived from sensory organ precursors are significantly reduced in number within the ventral eye field. We also observe gross abnormalities in bristle polarity, ommatidial organization, cellular adhesion and pigmentation in adult mid-RNAi flies. By combining a classical …

A Phylogeny Of Samydaceae Based On Nuclear Gbssi And Emb2765 Dna Sequences, Chelsa Williams

Honors Theses

Samydaceae are a tropical family of woody flowering plants, poorly known because they were once included in the ‘dustbin’ family Flacourtiaceae and because there are few economically important species. The family has recently been studied using DNA sequence data, but most of the data were from plastid DNA and some relationships had low statistical support. For this study, two nuclear regions, EMB2765 and GBSSI, were sequenced in order to affirm or refute the relationships inferred from plastid DNA and in order to find stronger statistical support for relationships. The data collected mostly affirm previously collected data from plastid DNA.

Molecular And Functional Characterization Of Tick Salivary Vti Protein Family, Ashley Villarreal

Honors Theses

Tick salivary glands serves as the organ of osmoregulation in ticks and are critical to the biological success of ticks both during extended period off the host and also during the feeding periods on the host. The salivary glands are the sites of pathogen development and saliva is the route of transmission. The importance of multifunctional salivary glands to tick survival and vector competency makes the glands a potential target for intervention. The complex process by which tick salivary gland proteins exit the glands and enter the host has been extensively studied, in what is called the SNARE hypothesis, soluble …

Exploring The Interaction Between Human Granulin-A (Hgrn-A) And Amyloid-Β (Aβ) Peptide, Michael Samel

Honors Theses

Alzheimer’s disease (AD) is the most common form of dementia affecting people over the age of 60, yet a detailed understanding of the molecular changes involved in AD remains a significant challenge to modern medicine. The hallmarks of an AD brain include the presence of senile plaques formed by a protein called amyloid-β (Aβ), along with inflammation of the brain. Aβ self-associates to form clumps of protein called “aggregates” which are known to be the primary toxic agents in AD pathology; however, several other proteins have also been implicated in this pathology. One such protein called progranulin (PGRN), which under …

Differences In Race And/Or Gender In Attitudes And Beliefs Towards Obesity Among Students At The University Of Southern Mississippi, Erick Brown

Honors Theses

Overweight and obesity have been described by various experts as critical problems in populations around the world, especially in the United States. These issues are so characterized because they affect numerous facets of life in this society. Researchers in the medical community have repeatedly described the health-related risks associated with obesity rates, asserting that higher risks of debilitating or fatal disease are tied to one’s level of obesity. They also say that obesity rates of populations are related to other disease rates, and many imply or clearly state that obesity is the cause and therefore the problem to be contested. …

Flora Of The Gopher Farm Sandhill, Wayne County, Mississippi, Shira Brittany Nicholson

Honors Theses

This study documents the vascular plants and common lichens of the Gopher Farm sandhill, Wayne County, Mississippi. The Gopher Farm sandhill is located within the Chickasawhay Ranger District of the DeSoto National Forest and is one of the most northerly located sandhills in the Coastal Plain of Mississippi. The sandhill was surveyed 11 times from the spring of 2011 to the spring of 2012, primarily during the spring and fall. The survey resulted in 180 species, including 15 lichens, 1 fern, 2 gymnosperms, and 162 flowering plants. Collections included two rare species (Carex tenax and Rhynchospora megalocarpa) and …