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Extreme Primary And Secondary Protein Structure Variability In The Chimeric Male-Transmitted Cytochrome C Oxidase Subunit Ii Protein In Freshwater Mussels: Evidence For An Elevated Amino Acid Substitution Rate In The Face Of Domain-Specific Purifying Selection, Eric G. Chapman, Helen Piontkivska, Jennifer M. Walker, Donald T. Stewart, Jason P. Curole, Walter R. Hoeh
Extreme Primary And Secondary Protein Structure Variability In The Chimeric Male-Transmitted Cytochrome C Oxidase Subunit Ii Protein In Freshwater Mussels: Evidence For An Elevated Amino Acid Substitution Rate In The Face Of Domain-Specific Purifying Selection, Eric G. Chapman, Helen Piontkivska, Jennifer M. Walker, Donald T. Stewart, Jason P. Curole, Walter R. Hoeh
Faculty Publications
Background
Freshwater unionoidean bivalves, and species representing two marine bivalve orders (Mytiloida and Veneroida), exhibit a mode of mtDNA inheritance involving distinct maternal (F) and paternal (M) transmission routes concomitant with highly divergent gender-associated mtDNA genomes. Additionally, male unionoidean bivalves have a ~550 bp 3' coding extension to the cox2 gene (Mcox2e), that is apparently absent from all other metazoan taxa.
Results
Our molecular sequence analyses of MCOX2e indicate that both the primary and secondary structures of the MCOX2e region are evolving much faster than other regions of the F and M COX2-COX1 gene …