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Full-Text Articles in Life Sciences
The Effect Of Embryonic Arsenic Exposure On The Sensorimotor Behavior Of Zebrafish (Danio Rerio), Laura Paye
The Effect Of Embryonic Arsenic Exposure On The Sensorimotor Behavior Of Zebrafish (Danio Rerio), Laura Paye
Honors College
The goal of this study is to determine the effect of arsenic exposure on vision in zebrafish (Danio rerio). The optic system of D. rerio is ideal for examining visual defects. Their eyes are similar to eyes of humans and can therefore be useful models in studies of human eye disease. Their optic system functions similarly to humans, so it is beneficial to observe how zebrafish are affected by contaminants in the environment. Arsenic is ubiquitous in groundwater, due to its natural presence in bed rock, but is elevated by human activities. In order to see any …
Effects Of Environmentally Relevant Transplacental Arsenic Exposure On Mouse (Mus Musculus) Hepatic Protein Expression, Jay Knowlton
Effects Of Environmentally Relevant Transplacental Arsenic Exposure On Mouse (Mus Musculus) Hepatic Protein Expression, Jay Knowlton
Honors College
Inorganic arsenic is a well-known toxic element found around the world, but the molecular mechanisms involved in arsenic toxicity are currently poorly understood. Arsenic has been linked to several types of cancer, diabetes, cardiovascular disease, and other metabolic diseases. This project explores the toxic effects of arsenic using mouse (Mus musculus) as a mammalian model organism. Preliminary data from the Van Beneden lab has shown that mice respond to low-dose, transplacental arsenic exposure in a dose-, sex-, and generation-dependent manner. The current study addresses a potential mechanism of toxicity by determining relative expression levels of pAKT/AKT1, a serine/threonine kinase that …
Characterizing Neutrophil Behavior In Zebrafish (Danio Rerio) In Response To Arsenic And Glucose, Jacob Longfellow
Characterizing Neutrophil Behavior In Zebrafish (Danio Rerio) In Response To Arsenic And Glucose, Jacob Longfellow
Honors College
The innate immune system recognizes self from non-self and is involved in pathogen clearance. Neutrophils are innate immune cells that quickly migrate to areas of infection or wounding. Neutrophils phagocytize pathogens and produce a respiratory burst that kills infectious agents. However, inappropriate presence and function of neutrophils contributes to many chronic inflammatory diseases. Environmental toxicants and other ingested compounds are known to impact innate immunity and neutrophil behavior. Two compounds of importance to the Maine population are arsenic and glucose, due to the presence of arsenic in Maine well water and the high rate of obesity and diabetes in Maine. …
Effects Of Arsenic Responsive P21 On Innate Immunity And Apoptosis In Zebrafish, Gabriel O. Vachon
Effects Of Arsenic Responsive P21 On Innate Immunity And Apoptosis In Zebrafish, Gabriel O. Vachon
Honors College
Arsenic is a heavy metal that is frequently found in drinking water, especially well-water in the Northeastern United States. Arsenic is thought to be involved with numerous negative health conditions. This project examined the impact of this environmental toxicant, on the zebrafish innate immune system. Specifically, this project characterized the gene encoding for the protein p21. The particular gene is cdkn1a (will be referred to here by its product "p21" both for the protein and gene itself which will be italicized) and had increased expression as a result of arsenic exposure from a previously complete microarray analysis. In attempt to …
Investigation Of The Mechanism Underlying Arsenic Disruption Of Mast Cell Degranulation, Alejandro Velez
Investigation Of The Mechanism Underlying Arsenic Disruption Of Mast Cell Degranulation, Alejandro Velez
Honors College
Exposure to arsenic (As) is a global health concern, according to the World Health Organization and Agency for Toxic Substances and Disease Registry. Prolonged exposure to this naturally occurring chemical has been linked to hyperkeratosis, type II diabetes, developmental abnormalities, and cancer. Some of the adverse health effects of As may be linked to its ability to alter cellular signal transduction. Recently, published work from the Gosse laboratory has shown that inorganic arsenite inhibits the signaling cascade leading to mast cell degranulation, a vital immune function, through an as-yet unknown mechanism.
Further work in the Gosse lab has suggested that …