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Allelic Variants Of Oprm1, Comt And Abcb1 On Pre-Withdrawal Sleep-Wake Regulation In The Opioid Exposed Neonate, Zakiah-Lee Meeks
Allelic Variants Of Oprm1, Comt And Abcb1 On Pre-Withdrawal Sleep-Wake Regulation In The Opioid Exposed Neonate, Zakiah-Lee Meeks
Honors College
Neonatal Abstinence Syndrome (NAS) is a neonatal medical condition of prenatal opioid withdrawal, secondary to prenatal exposure. NAS increases mortality and morbidity through seizure risk, and excessive sympathetic autonomic tone; which affects respiration and dysregulates sleep and feeding. Our laboratory has recruited more than 200 pregnant women who are in treatment for opiate dependence with methadone maintenance treatments. We have found that NAS severity is modulated by the presence of allelic variants of OPRM1 118A>G (μ-opiate receptor) and COMT 158 A>G (catechol-o-methyl transferase) genes, revealing a positive correlation between minor alleles of these two genes and severity reflected …