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Full-Text Articles in Life Sciences
Establishing Research Competitiveness In Biophysical Sciences In Maine, Michael Eckardt, Rosemary Smith, Barbara Knowles, Michael Grunze, Deirdre Mageean, Scott Collins, Heather Almquist, Robert Friesel, Thomas Maciag
Establishing Research Competitiveness In Biophysical Sciences In Maine, Michael Eckardt, Rosemary Smith, Barbara Knowles, Michael Grunze, Deirdre Mageean, Scott Collins, Heather Almquist, Robert Friesel, Thomas Maciag
University of Maine Office of Research Administration: Grant Reports
The Maine EPSCoR Research Infrastructure Improvement award is designed to enhance Maine's competitiveness in molecular biophysical sciences through a partnership between the University of Maine and Maine's non-profit research organizations. The proposed Biophysical Sciences Institute brings together University of Maine faculty in physics, chemistry, biology, mathematics, and spatial engineering, with biomedical researchers at the Jackson Laboratory and Maine Medical Center Research Institute. Maine EPSCoR proposes to hire additional tenure-track faculty in the fields of biophysics and advanced optics, biochemistry, structural biology, applied mathematics, computer science, image analysis and visualization, and material science. The new and existing investigators will form research …
Notch Regulation Of Human Breat Cancer Progression: Contrasting Roles For Notch Signaling, Christine F. O'Neill
Notch Regulation Of Human Breat Cancer Progression: Contrasting Roles For Notch Signaling, Christine F. O'Neill
Electronic Theses and Dissertations
Notch signaling is associated with activation of either oncogenic or tumor suppressor activities. The human mammary adenocarcinoma cell line, MDA-MB-231, was characterized in vitro and in xenografts in vivo to test the hypothesis that activation of Notch signaling regulates mammary tumor phenotype. Notch 1, Notch2, and Notch4 signaling was compared by stable expression of their constitutively active intracellular domains (ICD). Notch4 activation led to enhanced tumorigenicity, in addition to increased cell proliferation and survival in vitro, whereas the activation of Notch 1 or Notch2 decreased cell proliferation and survival, in which Notch2 increased apoptosis. Stably transfected cell lines were …