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Complete Annotations Of The Cluster E Mycobacteriophage Ukulele Genome And Characterization Of Cluster E Lysogeny Regulation, Gwendolyn M. Beacham
Complete Annotations Of The Cluster E Mycobacteriophage Ukulele Genome And Characterization Of Cluster E Lysogeny Regulation, Gwendolyn M. Beacham
Honors College
Mycobacteriophages (phages) are diverse and abundant viruses that infect species of the genus Mycobacterium. Mycobacteriophages are categorized into clusters based primarily on nucleotide similarity (18). Some clusters are well-characterized, while others, such as Cluster E, are poorly characterized (20). There are 54 members of Cluster E (39) including the phage Ukulele that was isolated at the University of Maine in 2011. This thesis is aimed towards characterizing Cluster E phages using Ukulele as a model. Cluster E phages have long tails of approximately 300 nm and they produce slightly turbid plaques on a lawn of Mycobacterium smegmatis. Putative …