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Full-Text Articles in Life Sciences
Epigallocatechin-3-Gallate (Egcg): New Therapeutic Perspectives For Neuroprotection, Aging, And Neuroinflammation For The Modern Age, Ashley Payne, Samuel N. Nahashon, Equar Taka, Getinet M. Adinew, Karam F. A. Soliman
Epigallocatechin-3-Gallate (Egcg): New Therapeutic Perspectives For Neuroprotection, Aging, And Neuroinflammation For The Modern Age, Ashley Payne, Samuel N. Nahashon, Equar Taka, Getinet M. Adinew, Karam F. A. Soliman
Agricultural and Environmental Sciences Faculty Research
Alzheimer's and Parkinson’s diseases are the two most common forms of neurodegenerative diseases. The exact etiology of these disorders is not well known; however, environmental, molecular, and genetic influences play a major role in the pathogenesis of these diseases. Using Alzheimer’s disease (AD) as the archetype, the pathological findings include the aggregation of Amyloid Beta (Aβ) peptides, mitochondrial dysfunction, synaptic degradation caused by inflammation, elevated reactive oxygen species (ROS), and cerebrovascular dysregulation. This review highlights the neuroinflammatory and neuroprotective role of epigallocatechin-3-gallate (EGCG): the medicinal component of green tea, a known nutraceutical that has shown promise in modulating AD progression …