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Full-Text Articles in Life Sciences
Privileged Structure: Novel Indane Scaffolds As Potential Anticancer And Anti-Inflammatory Agents, Kit Chan, Tao Zhang, Vilmar Cláudio Bandero-Filho, Andrew Moriarty, Paul Mccormick, Brian Mehigan, Cathcart Mary Clare, Robin Daly, Breandán Kennedy, Jacintha O'Sullivan, Neil Frankish, Helen Sheridan
Privileged Structure: Novel Indane Scaffolds As Potential Anticancer And Anti-Inflammatory Agents, Kit Chan, Tao Zhang, Vilmar Cláudio Bandero-Filho, Andrew Moriarty, Paul Mccormick, Brian Mehigan, Cathcart Mary Clare, Robin Daly, Breandán Kennedy, Jacintha O'Sullivan, Neil Frankish, Helen Sheridan
Conference papers
The identification and use of “privileged structures” can increase the reliability and shorten the process in the drug discovery and drug design (a-b). Indane scaffolds occur in various natural products and they constitute the privileged structure that is ubiquitous in many biologically and pharmaceutically active molecules (c-e). Our research group has been working on the synthesis and pharmacological activity of nature identical and synthetically modified indanes and indanones for 20 years. In the current study, the molecular design is centred on elaboration of a fern derived bioactive pharmacophore. The fern is used in traditional Taiwanese medicine to treat inflammation, allergy, …
From Nature To Medicinal Chemistry: Anti-Cancer Activity Of Novel Indane Scaffolds, Tao Zhang, Vilmar Bandero-Filho, Kit Chan, Lorraine O’Driscoll, Neil Frankish, Helen Sheridan
From Nature To Medicinal Chemistry: Anti-Cancer Activity Of Novel Indane Scaffolds, Tao Zhang, Vilmar Bandero-Filho, Kit Chan, Lorraine O’Driscoll, Neil Frankish, Helen Sheridan
Articles
No abstract provided.