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Full-Text Articles in Life Sciences
Bacterial Stress Responses To 1-Megahertz Pulsed Ultrasound In The Presence Of Microbubbles, Amy Cheng Vollmer, Sylvia D. Sakyiama Kwakye , '98, Matthew Evan Halpern , '98, E. Carr Everbach
Bacterial Stress Responses To 1-Megahertz Pulsed Ultrasound In The Presence Of Microbubbles, Amy Cheng Vollmer, Sylvia D. Sakyiama Kwakye , '98, Matthew Evan Halpern , '98, E. Carr Everbach
Engineering Faculty Works
Members of a panel of stress-responsive biosensors have been used to study the effect of megahertz frequency ultrasound onEscherichia coli. Insonification causes acoustic cavitation, the collapse of oscillating microbubbles in solution, which can damage bacterial cells. A focused 1-MHz ultrasound transducer, capable of generating a spatial peak pulse average intensity of 500 W/cm2, was used to treat liquid bacterial cultures. Stress-responsive promoters fused to luxCDABE allowed the continuous measurement of light produced as a result of protein damage, DNA damage, oxidative stress, and membrane perturbation. A promoter responsive to ammonia limitation was not transcriptionally activated under test conditions. In contrast …
Conceptual Breakthroughs In Developmental Biology, Scott F. Gilbert
Conceptual Breakthroughs In Developmental Biology, Scott F. Gilbert
Biology Faculty Works
No abstract provided.
Wormwholes: A Commentary On K.F. Schaffer's "Genes, Behavior, And Developmental Emergentism", Scott F. Gilbert, E. M. Jorgensen
Wormwholes: A Commentary On K.F. Schaffer's "Genes, Behavior, And Developmental Emergentism", Scott F. Gilbert, E. M. Jorgensen
Biology Faculty Works
Although Caenorhabditis elegans was chosen and modified to be an organism that would facilitate a reductionist program for neurogenetics, recent research has provided evidence for properties that are emergent from the neurons. While neurogenetic advances have been made using C. elegans which may be useful in explaining human neurobiology, there are severe limitations on C. elegans to explain any significant human behavior.