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Mechanism Of Dna Damage Checkpoint (Ddc)- Mediated Repression Of Histone Mrnas And Role Of Acetyl-Coa In Histone Transcription, Madhura Bhagwat
Mechanism Of Dna Damage Checkpoint (Ddc)- Mediated Repression Of Histone Mrnas And Role Of Acetyl-Coa In Histone Transcription, Madhura Bhagwat
Theses and Dissertations
My dissertation contains two projects. The first project is focused on the mechanism of DNA damage checkpoint (DDC)- mediated repression of histone mRNAs. The second project deals with the role of acetyl-CoA in histone transcription. Proliferating cells coordinate histone and DNA synthesis to maintain correct stoichiometric amounts for chromatin assembly. Histone mRNA levels must be repressed when DNA replication is inhibited to prevent toxicity and genome instability due to free non-chromatinized histone proteins. In the first project we show that, unlike in mammalian cells, DNA replication stress does not trigger decay of histone mRNAs in the yeast Saccharomyces cerevisiae. However, …