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Full-Text Articles in Life Sciences
Synthesis Of A Ggtase Substrate For Possible Oncogenesis Identification And Inhibition, Haley Dammar
Synthesis Of A Ggtase Substrate For Possible Oncogenesis Identification And Inhibition, Haley Dammar
Antonian Scholars Honors Program
Geranylgeranyl transferase (GGTase) is an enzyme involved in the prenylation of many proteins, including Ras proteins. Prenylation is the addition of a hydrophobic hydrocarbon chain to a molecule. This addition is responsible for the activation of signaling pathways connected to cell growth and development. A malfunction of prenylated Ras proteins can lead to uncontrollable cell growth and proliferation which can lead to many types of diseases, including cancer. This study focuses on the synthesis of a probe that is identical to the GGTase natural substrate, geranylgeranyldiphosphate (GGPP), with the only difference being the addition of a norbornene motif. This non-natural …
Possible Mechanism For First Sperm Precedence In The Hermaphroditic Freshwater Snail Planorbella Trivolvis, Cynthia Norton
Possible Mechanism For First Sperm Precedence In The Hermaphroditic Freshwater Snail Planorbella Trivolvis, Cynthia Norton
Biology Faculty Scholarship
In hermaphrodites the impact of mating order on fertilization success may not only shape the evolution of sperm competition but also influence gender roles during copulation. Planorbella trivolvis exhibit strong first sperm precedence – when snails are presented with two mates 24 hours apart, most eggs (over 80%) are fertilized by the first mate. This outcome may be explained if sperm from the first mate fill the storage organ so there is no room for additional sperm. It may also indicate a switch in gender role so that the focal animal acts as male, and not in the female role …