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Whole Genome Sequencing For Identification Of Putative Causative Alleles For Hemochromatosis In Horses, Anna M. Rauber-Ramos
Whole Genome Sequencing For Identification Of Putative Causative Alleles For Hemochromatosis In Horses, Anna M. Rauber-Ramos
Schultz-Werth Award Papers
Hemochromatosis is liver disorder in which excess iron is stored in the liver, leading to iron overload and extensive liver damage that can prove fatal. Based on human precedence, a genetic cause for idiopathic hemochromatosis in horses is suspected. Two horses with hemochromatosis were whole genome sequenced, with variants in candidate genes prioritized in analyses of potential pathogenicity. No clear putative variants were found to be present in both horses, suggesting an etiology more complex than the initially suspected Mendelian inheritance. A heterozygous nonsense mutation in STEAP3 metalloreductase (STEAP3) was identified as a potential contributor to hemochromatosis in one of …
Development And Diagnostic Application Of Monoclonal Antibodies Against Swine Acute Diarrhea Syndrome Coronavirus (Sads-Cov), Molly Kroeger
Development And Diagnostic Application Of Monoclonal Antibodies Against Swine Acute Diarrhea Syndrome Coronavirus (Sads-Cov), Molly Kroeger
Schultz-Werth Award Papers
Swine Acute Diarrhea Syndrome Coronavirus (SADS-CoV) is a member of the Coronaviridae family. The virus is associated with severe small intestine inflammation and diarrhea in suckling piglets. In 2017, SADS-CoV was first detected and identified as the causative agent of a devasting swine disease outbreak in southern China. Routine monitoring and early detection of the source of infection is therefore integral to the prevention and control of a SADS-CoV outbreak in the United States. However, the United States does not currently have any diagnostic or surveillance tests to identify this emerging disease. To address these industry needs, we developed monoclonal …