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Genotype-Phenotype Diversity Of Beta-Thalassemia In Malaysia: Treatment Options And Emerging Therapies, Maryanne Jin Ai Tan Maryanne Dec 2010

Genotype-Phenotype Diversity Of Beta-Thalassemia In Malaysia: Treatment Options And Emerging Therapies, Maryanne Jin Ai Tan Maryanne

Mary Anne Tan Jin Ai

The haemoglobinopathies and thalassemias represent the most common inherited monogenic disorders in the world1. Beta-thalassaemia major is an ongoing public health problem in Malaysia2. Prior to 2004, the country had no national policy for screening and registry for thalassemia. In the absence of a national audit, the true figure of the extent of thalassemia in the Malaysian population was largely presumptive from micro-mapping studies from various research workers in the country. The estimated carrier rate for beta-thalassemia in Malaysia is 3.5-4%. There were 4768 transfusion dependent thalassemia major patients as of May 2010 (Data from National Thalassemia Registry).


Susceptibility Of Field-Collected Aedes Aegypti (L.) (Diptera: Culicidae) To Bacillus Thuringiensis Israelensis And Temephos, Mohd Sofian Bin Azirun Jan 2010

Susceptibility Of Field-Collected Aedes Aegypti (L.) (Diptera: Culicidae) To Bacillus Thuringiensis Israelensis And Temephos, Mohd Sofian Bin Azirun

Mohd Sofian Bin Azirun

The susceptibility status of field-collected Aedes aegypti (L.) from a dengue endemic area to Bacillus thuringiensis israelensis (Bti) and temephos was determined. Since August 2007, biweekly ovitrap surveillance (OS) was conducted for 12 mo in 2 sites, A & B, in Shah Alam, Selangor. Site A was treated with a Bti formulation, VectoBac® WG at 500 g/ha, from December 2007 - June 2008 while Site B was subjected to routine dengue vector control activities conducted by the local municipality. Aedes aegypti larvae collected from OS in both sites were bred until F3 and evaluated for their susceptibility. The larvae were …