Life Sciences Commons^™

Closing The Gap Between The Industry And Higher Education Institutions- Case Examples From East African Region, Deogratias Harorimana Mr

Dr Deogratias Harorimana

Much complained about is the quality of graduates Universities put on the labour market. Less talked about however is why knowledge institutions seems to be bad knowledge managers. In this presentation I argue that DIRECT collaborative relationship between Industry,Governments and Higher Education Institutions is a per-requisite.Good relationship is key to building such a successful knowledge transfer strategies between Industries and Educational and Research Institutions. This paper explores what makes a good Knowledge Transfer Partnership Strategy and highlights some key lessons for businesses, Universities and Government bodies. This paper was a Key note presentation to the Annual International Conference on Building …

Species Boundaries And Evolutionary Lineages In The Blue Green Damselfishes Chromis Viridis And Chromis Atripectoralis (Pomacentridae), Philadelphia University

Philadelphia University, Jordan

No abstract provided.

Rwanda National Customer Satisfaction Survey: Results And Conclusions, Deogratias Harorimana

Dr Deogratias Harorimana

It can be said that development practice requires more than financial and manpower inputs. Rwanda, in 1994 suffered a Genocide. The Society,collectively and under the leadership of His Excellence Paul Kagame the current elected President of Rwanda came together and designed strategies that would propel Rwanda to a Middle-Income, Private Sector Led Economy by the Year 2020.

In 2009, a client seating in one of the Hotels in a Suburb of Remera, in Kigali City, complained about poor service delivery he was experiencing from the waitress staff.Using his Blackberry message, the client forwarded an email to some of the RDB …

Enterprise Development Policies And Capacity-Building In Science, Technology And Innovation (Sti)-Response To The Issue Note, Deogratias Harorimana

Dr Deogratias Harorimana

Enterprise Development, Investment and Business Climate are all important for economic growth. But what policies, strategies are needed to make economic growth a reality. The author has followed one of the World's fastest reformer and emerging nation in the Heart of Africa-Rwanda. The paper shares lessons and practical aspects related to building an entrepreneurial population, and building a government which is a facilitator of business climate

Abd: Advanced Biotechnological Directory For Protein Sequence And Structure Analysis, Azhaguraj Ramakrishnan

Azhaguraj Ramakrishnan

Over the past decades, a number of computational tools for structure prediction have been developed. It is critical that the biological community is aware of such tools and is able to interpret their results in an informed way. Rapid increase in protein sequence information from genome sequencing projects demand the intervention of bioinformatics tools to recognize interesting gene products and associated function often multiple algorithms need to be employed to improve accuracy in prediction and several structure prediction. Here we report the availability of an ABD as a bioinformatics online package dedicated for Insilco analysis of protein sequence and structure …

Wavelet-Based Functional Linear Mixed Models: An Application To Measurement Error–Corrected Distributed Lag Models, Elizabeth J. Malloy, Jeffrey S. Morris, Sara D. Adar, Helen Suh, Diane R. Gold, Brent A. Coull

Jeffrey S. Morris

Frequently, exposure data are measured over time on a grid of discrete values that collectively define a functional observation. In many applications, researchers are interested in using these measurements as covariates to predict a scalar response in a regression setting, with interest focusing on the most biologically relevant time window of exposure. One example is in panel studies of the health effects of particulate matter (PM), where particle levels are measured over time. In such studies, there are many more values of the functional data than observations in the data set so that regularization of the corresponding functional regression coefficient …

Members’ Discoveries: Fatal Flaws In Cancer Research, Jeffrey S. Morris

Jeffrey S. Morris

A recent article published in The Annals of Applied Statistics (AOAS) by two MD Anderson researchers—Keith Baggerly and Kevin Coombes—dissects results from a highly-influential series of medical papers involving genomics-driven personalized cancer therapy, and outlines a series of simple yet fatal flaws that raises serious questions about the veracity of the original results. Having immediate and strong impact, this paper, along with related work, is providing the impetus for new standards of reproducibility in scientific research.

Statistical Contributions To Proteomic Research, Jeffrey S. Morris, Keith A. Baggerly, Howard B. Gutstein, Kevin R. Coombes

Jeffrey S. Morris

Proteomic profiling has the potential to impact the diagnosis, prognosis, and treatment of various diseases. A number of different proteomic technologies are available that allow us to look at many proteins at once, and all of them yield complex data that raise significant quantitative challenges. Inadequate attention to these quantitative issues can prevent these studies from achieving their desired goals, and can even lead to invalid results. In this chapter, we describe various ways the involvement of statisticians or other quantitative scientists in the study team can contribute to the success of proteomic research, and we outline some of the …

Informatics And Statistics For Analyzing 2-D Gel Electrophoresis Images, Andrew W. Dowsey, Jeffrey S. Morris, Howard G. Gutstein, Guang Z. Yang

Jeffrey S. Morris

Whilst recent progress in ‘shotgun’ peptide separation by integrated liquid chromatography and mass spectrometry (LC/MS) has enabled its use as a sensitive analytical technique, proteome coverage and reproducibility is still limited and obtaining enough replicate runs for biomarker discovery is a challenge. For these reasons, recent research demonstrates the continuing need for protein separation by two-dimensional gel electrophoresis (2-DE). However, with traditional 2-DE informatics, the digitized images are reduced to symbolic data though spot detection and quantification before proteins are compared for differential expression by spot matching. Recently, a more robust and automated paradigm has emerged where gels are directly …

Bayesian Random Segmentationmodels To Identify Shared Copy Number Aberrations For Array Cgh Data, Veerabhadran Baladandayuthapani, Yuan Ji, Rajesh Talluri, Luis E. Nieto-Barajas, Jeffrey S. Morris

Jeffrey S. Morris

Array-based comparative genomic hybridization (aCGH) is a high-resolution high-throughput technique for studying the genetic basis of cancer. The resulting data consists of log fluorescence ratios as a function of the genomic DNA location and provides a cytogenetic representation of the relative DNA copy number variation. Analysis of such data typically involves estimation of the underlying copy number state at each location and segmenting regions of DNA with similar copy number states. Most current methods proceed by modeling a single sample/array at a time, and thus fail to borrow strength across multiple samples to infer shared regions of copy number aberrations. …

Quantitative Comparison Of Genomic-Wide Protein Domain Distributions, Arli A. Parikesit, Peter F. Stadler, Sonja J. Prohaska

Arli A Parikesit

Investigations into the origins and evolution of regulatory mechanisms require quantitative estimates of the abundance and co-occurrence of functional protein domains among distantly related genomes. Currently available databases, such as the SUPERFAMILY, are not designed for quantitative comparisons since they are built upon transcript and protein annotations provided by the various different genome annotation projects. Large biases are introduced by the differences in genome annotation protocols, which strongly depend on the availability of transcript information and well-annotated closely related organisms. Here we show that the combination of de novo gene predictors and subsequent HMM-based annotation of SCOP domains in the …

Survey Report On Training And Spending On Customer Care Services, Deogratias Harorimana Sr

Dr Deogratias Harorimana

In a bid to promote and develop good customer care service in various sectors of Rwandan economy, a survey was conducted to assess progress and trends on customer service capacity building. Although shortcomings are there, there have been efforts and registered trends across the country on service delivery front. Investment in Capacity Building IS happening in certain sectors but this is unevenly distributed. In 2008 companies had started recognizing the significance of good service and cultivate a good working environment and training. From 2009, there was a decline in investment in capacity building in front office and key service delivery …