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Differential Expression Of Ompc And Ompf In Multidrug-Resistant Shigella Dysenteriae And Shigella Flexneri By Aqueous Extract Of Aegle Marmelos, Altering Its Susceptibility Toward Beta-Lactam Antibiotics, Raja Sb, Murali Mr, Devaraj Sn
Differential Expression Of Ompc And Ompf In Multidrug-Resistant Shigella Dysenteriae And Shigella Flexneri By Aqueous Extract Of Aegle Marmelos, Altering Its Susceptibility Toward Beta-Lactam Antibiotics, Raja Sb, Murali Mr, Devaraj Sn
Murali Malliga Raman
Steadily increasing resistance among Shigella to beta-lactams, aminoglycosides, and tetracycline has compromised the utility of these commonly used antimicrobial agents. Also, undesirable side effects of certain antibiotics have triggered immense interest in search of alternative therapies using medicinal plants. One such medicinal plant used since ancient times to cure diarrhea is Aegle marmelos. The present study exemplifies the susceptibility of beta-lactam-resistant Shigella dysenteriae and Shigella flexneri toward beta-lactam antibiotics, when grown in the presence of aqueous extract of A. marmelos (AEAM), by altering porin channels. This was demonstrated by antibiotic sensitivity test using disc diffusion method and MIC test. Susceptibility …