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Isolation And Partial Characterization Of A Novel Lectin From Aegle Marmelos Fruit And Its Effect On Adherence And Invasion Of Shigella To Ht29 Cells, Raja Sb, Murali Mr, Kumar Nk, Devaraj Sn
Isolation And Partial Characterization Of A Novel Lectin From Aegle Marmelos Fruit And Its Effect On Adherence And Invasion Of Shigella To Ht29 Cells, Raja Sb, Murali Mr, Kumar Nk, Devaraj Sn
Murali Malliga Raman
Lectins are a class of ubiquitous proteins/glycoproteins that are abundantly found in nature. Lectins have unique carbohydrate binding property and hence have been exploited as drugs against various infectious diseases. We have isolated one such novel lectin from the fruit pulp of Aegle marmelos. The isolated lectin was partially characterised and its effect against Shigella dysenteriae infection was evaluated. The isolated lectin was found to be a dimeric protein with N-acetylgalactosamine, mannose and sialic acid binding specificity. The effect of Aegle marmelos fruit lectin on the adherence of Shigella dysenteriae to human colonic epithelial cells (HT29 cells) was evaluated by …
Determining The Effectiveness Of The Different Preparation Protocols For Platelet-Rich Plasma (Prp) In Yielding Higher Concentrations Of Platelets, Kavitha G, Sangeetha Vn, Shani S, Murali Mr, Raja Ea, Rukmanikanthan S, David C
Determining The Effectiveness Of The Different Preparation Protocols For Platelet-Rich Plasma (Prp) In Yielding Higher Concentrations Of Platelets, Kavitha G, Sangeetha Vn, Shani S, Murali Mr, Raja Ea, Rukmanikanthan S, David C
Murali Malliga Raman
INTRODUCTION: Despite the various methods described in producing platelet-rich plasma (PRP), it is well established that this biological product in its many preparations have been proven to enhance wound healing. However, very little have been known about the efficacy of these methods hence there is a lack of evidence in the superiority of one method over another. Thus, a study was conducted to compare these different protocols to determine which produces the highest concentration of platelets. METHODS: Peripheral blood was obtained from 24 healthy volunteers. Four different protocols using similar 2 step centrifugation methods of preparing PRP were applied to …
Imperatorin A Furocoumarin Inhibits Periplasmic Cu-Zn Sod Of Shigella Dysenteriae Their By Modulates Its Resistance Towards Phagocytosis During Host Pathogen Interaction, Raja Sb, Murali Mr, Roopa K, Devaraj Sn
Imperatorin A Furocoumarin Inhibits Periplasmic Cu-Zn Sod Of Shigella Dysenteriae Their By Modulates Its Resistance Towards Phagocytosis During Host Pathogen Interaction, Raja Sb, Murali Mr, Roopa K, Devaraj Sn
Murali Malliga Raman
Shigella dysenteriae continues to be a major health problem, which leads to death, due to diarrhoea and dysentery, predominantly in children below the age of 5. Bacterial invasion of the colonic epithelium leads to severe inflammation together with bacterial dissemination generates abscesses and ulcerations. Periplasmic copper, zinc super oxide dismutase of Shigella protects it from exogenous superoxide produced by host, during its invasion. Hence, in present study an attempt was made to study the effect of aqueous extract of Aegle marmelos on host and pathogen defence. Histology analysis of rat ileal loop showed the loss of virulence in aqueous extract …