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Pva-Chitosan Composite Hydrogel Versus Alginate Beads As A Potential Mesenchymal Stem Cell Carrier For The Treatment Of Focal Cartilage Defects: An In Vivo Study Using Rabbits, Dashtdar H, Murali Mr, Abbas Aa, Suhaeb Am, Selvaratnam L, Tay Lx, Kamarul T
Pva-Chitosan Composite Hydrogel Versus Alginate Beads As A Potential Mesenchymal Stem Cell Carrier For The Treatment Of Focal Cartilage Defects: An In Vivo Study Using Rabbits, Dashtdar H, Murali Mr, Abbas Aa, Suhaeb Am, Selvaratnam L, Tay Lx, Kamarul T
Murali Malliga Raman
PURPOSE: To investigate whether mesenchymal stem cells (MSCs) seeded in novel polyvinyl alcohol (PVA)-chitosan composite hydrogel can provide comparable or even further improve cartilage repair outcomes as compared to previously established alginate-transplanted models. METHODS: Medial femoral condyle defect was created in both knees of twenty-four mature New Zealand white rabbits, and the animals were divided into four groups containing six animals each. After 3 weeks, the right knees were transplanted with PVA-chitosan-MSC, PVA-chitosan scaffold alone, alginate-MSC construct or alginate alone. The left knee was kept as untreated control. Animals were killed at the end of 6 months after transplantation, and …