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In Silico, In Vitro And In Vivo Assessment Of Safety And Anti-Inflammatory Activity Of Curcumin., Venkata M, Sripathy R, Anjana D, Somashekara N, Krishnaraju A, Krishanu S, Murali Mr, Verma Sr, Ramchand Cn
In Silico, In Vitro And In Vivo Assessment Of Safety And Anti-Inflammatory Activity Of Curcumin., Venkata M, Sripathy R, Anjana D, Somashekara N, Krishnaraju A, Krishanu S, Murali Mr, Verma Sr, Ramchand Cn
Murali Malliga Raman
Problem statement: Curcumin the active component of turmeric is known for its wide biological actions. Extensive studies on curcumin highlighted its anti-inflammatory, anti-oxidant, anti-microbial, anti-carcinogenic and anti-coagulant activity. The anti-inflammatory activities of curcumin have been demonstrated both in vitro and in vivo. Though curcumin and its anti-inflammatory properties are well documented, the exact mechanism of action and effective in vivo dosage required for potential anti-inflammatory activity of curcumin are yet to be determined. The current work reflects in identfying the the role curcumin in the inflmmatory cascade and arriving at an optimal effective dose (ED50). Approach: The objective of the …