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- Anti-inflammatory activity (1)
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- IL1b/Akt crosstalk (1)
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Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
In Silico, In Vitro And In Vivo Assessment Of Safety And Anti-Inflammatory Activity Of Curcumin., Venkata M, Sripathy R, Anjana D, Somashekara N, Krishnaraju A, Krishanu S, Murali Mr, Verma Sr, Ramchand Cn
In Silico, In Vitro And In Vivo Assessment Of Safety And Anti-Inflammatory Activity Of Curcumin., Venkata M, Sripathy R, Anjana D, Somashekara N, Krishnaraju A, Krishanu S, Murali Mr, Verma Sr, Ramchand Cn
Murali Malliga Raman
Problem statement: Curcumin the active component of turmeric is known for its wide biological actions. Extensive studies on curcumin highlighted its anti-inflammatory, anti-oxidant, anti-microbial, anti-carcinogenic and anti-coagulant activity. The anti-inflammatory activities of curcumin have been demonstrated both in vitro and in vivo. Though curcumin and its anti-inflammatory properties are well documented, the exact mechanism of action and effective in vivo dosage required for potential anti-inflammatory activity of curcumin are yet to be determined. The current work reflects in identfying the the role curcumin in the inflmmatory cascade and arriving at an optimal effective dose (ED50). Approach: The objective of the …
Differential Expression Of Gastric Muc5ac In Colonic Epithelial Cells: Tff-3 Wired Il1Β/Akt Crosstalk Induced Mucosal Immune Response Against Shigella Dysenteriae Infection, Raja Sb, Murali Mr, Devaraj H, Devaraj Sn
Differential Expression Of Gastric Muc5ac In Colonic Epithelial Cells: Tff-3 Wired Il1Β/Akt Crosstalk Induced Mucosal Immune Response Against Shigella Dysenteriae Infection, Raja Sb, Murali Mr, Devaraj H, Devaraj Sn
Murali Malliga Raman
An understanding of the signaling mechanism(s) that regulate the differential expression of gastric mucin MUC5AC in colonic epithelial cells would contribute significantly to investigations of its role in colonic mucosa infected with the bacterial pathogen Shigella dysenteriae. Here we show that S. dysenteriae-Sinduced expression of interleukin-1β upregulates MUC2 expression and the differential expression of MUC5AC. Differential expression of MUC5AC involves crosstalk between interleukin-1β and Akt, whereby the trefoil factor family peptide TFF3 activates Akt by phosphorylation of EGFR. TFF3 also downregulates E-cadherin expression, causing accumulation of β-catenin in the cytosol. Phosphorylation of GSK-3β (inactivated) by activated Akt inhibits ubiquitylation of …
Mechanical And Functional Assessment Of The Wrist Affected By Rheumatoid Arthritis: A Finite Element Analysis, Bajuri Mn, Kadir Mr, Murali Mr, Kamarul T
Mechanical And Functional Assessment Of The Wrist Affected By Rheumatoid Arthritis: A Finite Element Analysis, Bajuri Mn, Kadir Mr, Murali Mr, Kamarul T
Murali Malliga Raman
Understanding the pathomechanics involved in rheumatoid arthritis (RA) of the wrist provides valuable information, which will invariably allow various therapeutic possibilities to be explored. The computational modelling of this disease permits the appropriate simulation to be conducted seamlessly. A study that underpins the fundamental concept that produces the biomechanical changes in a rheumatoid wrist was thus conducted through the use of finite element method. The RA model was constructed from computed tomography datasets, taking into account three major characteristics: synovial proliferation, cartilage destruction and ligamentous laxity. As control, a healthy wrist joint model was developed in parallel and compared. Cartilage …