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Articles 1 - 10 of 10
Full-Text Articles in Life Sciences
Mapping A Gene For Familial Hypertrophic Cardiomyopathy To Chromosome 14q1, John Jarcho, William Mckenna, J.A. Peter Pare, Scott Solomon, Randall Holcombe, Shaughan Dickie, Tatjana Levi, Helen Donis-Keller, J.G. Seidman, Christine Seidman
Mapping A Gene For Familial Hypertrophic Cardiomyopathy To Chromosome 14q1, John Jarcho, William Mckenna, J.A. Peter Pare, Scott Solomon, Randall Holcombe, Shaughan Dickie, Tatjana Levi, Helen Donis-Keller, J.G. Seidman, Christine Seidman
Helen Donis-Keller
To identify the chromosomal location of a gene responsible for familial hypertrophic cardiomyopathy, we used clinical and molecular genetic techniques to evaluate the members of a large kindred. Twenty surviving and 24 deceased family members had hypertrophic cardiomyopathy; 58 surviving members were unaffected. Genetic-linkage analyses were performed with polymorphic DNA loci dispersed throughout the entire genome, to identify a locus that was inherited with hypertrophic cardiomyopathy in family members. The significance of the linkage detected between the disease locus and polymorphic loci was assessed by calculating a lod score (the logarithm of the probability of observing coinheritance of two loci, …
Mapping The Gene For Hereditary Cutaneous Malignant Melanoma-Dysplastic Nevus To Chromosome 1p, Sherri J. Bale, Nicholas C. Dracopoli, Margaret A. Tucker, Wallace H. Clark, Jr., Mary C. Fraser, Ben Z. Stanger, Philip Green, Helen Donis-Keller, David E. Housman, Mark H. Greene
Mapping The Gene For Hereditary Cutaneous Malignant Melanoma-Dysplastic Nevus To Chromosome 1p, Sherri J. Bale, Nicholas C. Dracopoli, Margaret A. Tucker, Wallace H. Clark, Jr., Mary C. Fraser, Ben Z. Stanger, Philip Green, Helen Donis-Keller, David E. Housman, Mark H. Greene
Helen Donis-Keller
We used molecular genetic techniques and multipoint linkage analyses to locate the gene responsible for cutaneous malignant melanoma-dysplastic nevus. We evaluated 99 relatives and 26 spouses in six families with a predisposition to melanoma. Thirty-four family members had cutaneous malignant melanoma, and 31 of these 34 also had histologically confirmed dysplastic nevi. Twenty-four family members had dysplastic nevi alone. An analysis of the cosegregation of the cutaneous malignant melanoma–dysplastic nevus trait with 26 polymorphic DNA markers on the short arm of chromosome 1 demonstrated the presence of a gene for susceptibility to melanoma. The gene was located between an anonymous …
Pericellular Conditions Regulate Extent Of Cell-Mediated Compaction Of Collagen Gels, Mark Stevenson, Alisha Sarang-Sieminski, Claire Mcleod, Fitzroy Byfield, Victor Barocas, Ketih Gooch
Pericellular Conditions Regulate Extent Of Cell-Mediated Compaction Of Collagen Gels, Mark Stevenson, Alisha Sarang-Sieminski, Claire Mcleod, Fitzroy Byfield, Victor Barocas, Ketih Gooch
Alisha L. Sarang-Sieminski
Cell-mediated compaction of the extracellular matrix (ECM) plays a critical role in tissue engineering, woundhealing, embryonic development, and many disease states. The ECM is compacted as a result of cellular traction forces. Wehypothesize that a cell mechanically remodels the nearby ECM until some target conditions are obtained, and then the cell stopscompacting. A key feature of this hypothesis is that ECM compaction primarily occurs in the pericellular region and the propertiesof the ECM in the pericellular region govern cellular force generation. We developed a mathematical model to describe theamount of macroscopic compaction of cell-populated collagen gels in terms of the …
Ena/Vasp Is Required For Endothelial Barrier Function In Vivo, Craig Furman, Alisha L. Sieminski, Adam V. Kwiatkowski, Douglas A. Rubinson, Eliza Vasile, Roderick T. Bronson, Reinhard Fassler
Ena/Vasp Is Required For Endothelial Barrier Function In Vivo, Craig Furman, Alisha L. Sieminski, Adam V. Kwiatkowski, Douglas A. Rubinson, Eliza Vasile, Roderick T. Bronson, Reinhard Fassler
Alisha L. Sarang-Sieminski
Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) proteins are key actin regulators that localize at regions of dynamic actin remodeling, including cellular protrusions and cell-cell and cell-matrix junctions. Several studies have suggested that Ena/VASP proteins are involved in the formation and function of cellular junctions. Here, we establish the importance of Ena/VASP in endothelial junctions in vivo by analysis of Ena/VASP-deficient animals. In the absence of Ena/VASP, the vasculature exhibits patterning defects and lacks structural integrity, leading to edema, hemorrhaging, and late stage embryonic lethality. In endothelial cells, we find that Ena/VASP activity is required for normal F-actin content, actomyosin contractility, and proper response …
Soluble Aluminium In Acidic Soils: Principles And Practicalities, G. S.P. Ritchie
Soluble Aluminium In Acidic Soils: Principles And Practicalities, G. S.P. Ritchie
Geraldine Ritchie
Our ability to predict toxic quantities of aluminium (Al) in acidic soils is limited by our understanding of the interactions between different solid forms of Al in solution and our lack of knowledge of which form control soluble Al. This review briefly considers each type of solid form of Al, particularly from a kinetic point of view and discusses models that have been developed to predict release of Al from individual forms. More comprehensive models (i.e. more than one source or sink of Al) are then discussed as well as the interactions between different solid sources of Al.
Rethinking Mechanistic Explanation, Stuart Glennan
Rethinking Mechanistic Explanation, Stuart Glennan
Stuart Glennan
Philosophers of science typically associate the causal-mechanical view of scientific explanation with the work of Railton and Salmon. In this paper I shall argue that the defects of this view arise from an inadequate analysis of the concept of mechanism. I contrast Salmon's account of mechanisms in terms of the causal nexus with my own account of mechanisms, in which mechanisms are viewed as complex systems. After describing these two concepts of mechanism, I show how the complex-systems approach avoids certain objections to Salmon's account of causal-mechanical explanation. I conclude by discussing how mechanistic explanations can provide understanding by unification.
Cross-Sectional And Longitudinal Associations Of Neighborhood Characteristics With Inflammatory Markers: Findings From The Multi-Ethnic Study Of Atherosclerosis, Aydin Nazmi, Ana Diez Roux, Nalini Ranjit, Teresa E. Seeman, Nancy S. Jenny
Cross-Sectional And Longitudinal Associations Of Neighborhood Characteristics With Inflammatory Markers: Findings From The Multi-Ethnic Study Of Atherosclerosis, Aydin Nazmi, Ana Diez Roux, Nalini Ranjit, Teresa E. Seeman, Nancy S. Jenny
Aydin Nazmi
We investigated cross-sectional associations of neighborhood deprivation, problems, safety, and cohesion with circulating levels of fibrinogen, interleukin-6, and C-reactive protein (n=5370) and longitudinal associations with changes in IL-6 over a 3–4 year period (n=946). In cross-sectional analyses, higher levels of neighborhood deprivation and problems were associated with higher levels of all three inflammatory markers, whereas higher levels of safety were associated with lower levels. Fibrinogen remained associated with all neighborhood characteristics except cohesion and IL-6 remained associated with safety after adjustment for race and SES. In longitudinal analyses, higher levels of neighborhood deprivation and problems, and lower levels of safety …
The Influence Of Persistent Pathogens On Circulating Levels Of Inflammatory Markers: A Cross-Sectional Analysis From The Multi-Ethnic Study Of Atherosclerosis, Aydin Nazmi, Ana V. Diez-Roux, Nancy S. Jenny, Michael Y. Tsai, Moyses Szklo, Allison E. Aiello
The Influence Of Persistent Pathogens On Circulating Levels Of Inflammatory Markers: A Cross-Sectional Analysis From The Multi-Ethnic Study Of Atherosclerosis, Aydin Nazmi, Ana V. Diez-Roux, Nancy S. Jenny, Michael Y. Tsai, Moyses Szklo, Allison E. Aiello
Aydin Nazmi
Background: Systemic inflammation is linked to cardiovascular risk, but the influence of persistent pathogens, which are conventionally dichotomously categorized, on circulating levels of inflammatory markers is not clear. Antibody levels of pathogens have not been examined in relation to inflammation. Methods: Using data from a subsample of the Multi-Ethnic Study of Atherosclerosis, we examined circulating levels of interleukin-6 (IL-6), C-reactive protein (CRP) and fibrinogen in relation to five common persistent pathogens: cytomegalovirus, herpes simplex virus-1, Hepatitis A virus, Helicobacter pylori and Chlamydia pneumoniae. We tested the hypothesis that the number of seropositive pathogens (based on conventional cut-off points) would not …
Catecholamines Increase Conjugative Gene Transfer Between Enteric Bacteria., Amit Kumar
Catecholamines Increase Conjugative Gene Transfer Between Enteric Bacteria., Amit Kumar
Amit Kumar, DVM, MS, PhD
The ability of pathogenic bacteria to sense and respond to periods of host stress is critical to their lifestyle. Adrenaline and norepinephrine are catecholamines that mediate acute host stress in vertebrates and invertebrates. Catecholamines are also used as environmental cues to enhance growth, motility and virulence of bacterial pathogens via specific binding receptors. Incidence of multidrug resistant and highly virulent bacterial pathogens is on the rise, and majority of the genes for antimicrobial resistance (AMR) and virulence are carried on horizontally transferable genetic elements. Conjugation machinery offers an efficient method for acquisition of AMR and virulence genes, which may be …
Influence Of Molecular Resolution On Sequence-Based Discovery Of Ecological Diversity Among Synechococcus Populations In An Alkaline Siliceous Hot Spring Microbial Mat, Melanie C. Melendrez, R. K. Lange, Frederick M. Cohan, David M. Ward
Influence Of Molecular Resolution On Sequence-Based Discovery Of Ecological Diversity Among Synechococcus Populations In An Alkaline Siliceous Hot Spring Microbial Mat, Melanie C. Melendrez, R. K. Lange, Frederick M. Cohan, David M. Ward
Frederick M. Cohan
No abstract provided.