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Stress Is A Principal Factor That Promotes Tobacco Use In Females, Laura Elena O'Dell Ph.D.
Stress Is A Principal Factor That Promotes Tobacco Use In Females, Laura Elena O'Dell Ph.D.
Laura Elena O'Dell
Tobacco use is a major economic and health problem. It is particularly concerning that women consume more tobacco products, have a more difficult time quitting smoking, and are less likely to benefit fromsmoking cessation therapy than men. As a result, women are at higher risk of developing tobacco-related diseases. Clinical evidence suggests that women are more susceptible to anxiety disorders, and are more likely to smoke in order to cope with stress than men. During smoking abstinence, women experience more intense anxiety than men and report that the anxiety-reducing effects of smoking are the main reason for their continued tobacco …
Enhanced Vulnerability To Tobacco Use In Persons With Diabetes: A Behavioral And Neurobiological Framework, Laura Elena O'Dell Ph.D.
Enhanced Vulnerability To Tobacco Use In Persons With Diabetes: A Behavioral And Neurobiological Framework, Laura Elena O'Dell Ph.D.
Laura Elena O'Dell
Tobacco use significantlymagnifies the negative health complications associatedwith diabetes. Although tobacco use is strongly discouraged in personswith diabetes, clinical evidence suggests that they often continue to smoke and have more difficulty quitting despite serious contraindications. Here, we suggest that a potential reason for enhanced vulnerability to tobacco use in persons with diabetes is greater rewarding effects of nicotine. This review summarizes pre-clinical evidence indicating that the rewarding effects of nicotine are enhanced in rodent models of type 1 and type 2 diabetes. We also provide a framework of neurobiological mechanisms that are posited to promote tobacco use in personswith diabetes. …
A Mechanistic Hypothesis Of The Factors That Enhance Vulnerability To Nicotine Use In Females, Laura O'Dell
A Mechanistic Hypothesis Of The Factors That Enhance Vulnerability To Nicotine Use In Females, Laura O'Dell
Laura Elena O'Dell
Women are particularly more vulnerable to tobacco use than men. This review proposes a unifying hypothesis that females experience greater rewarding effects of nicotine and more intense stress produced by withdrawal than males. We also provide a neural framework whereby estrogen promotes greater rewarding effects of nicotine in females via enhanced dopamine release in the nucleus accumbens (NAcc). During withdrawal, we suggest that corticotropin-releasing factor (CRF) stress systems are sensitized and promote a greater suppression of dopamine release in the NAcc of females versus males. Taken together, females display enhanced nicotine reward via estrogen and amplified effects of withdrawal via …
Nico-Teen: Neural Substrates That Mediate Adolescent Tobacco Abuse., Laura O'Dell
Nico-Teen: Neural Substrates That Mediate Adolescent Tobacco Abuse., Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Nico-Teen: Neural Substrates That Mediate Adolescent Tobacco Abuse., Laura O'Dell
Nico-Teen: Neural Substrates That Mediate Adolescent Tobacco Abuse., Laura O'Dell
Laura Elena O'Dell
No abstract provided.
The Effects Of Opioids And Opioid Analogs On Animal And Human Endocrine Systems, Laura O'Dell
The Effects Of Opioids And Opioid Analogs On Animal And Human Endocrine Systems, Laura O'Dell
Laura Elena O'Dell
No abstract provided.