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Tlr4, Ethanol, And Lipid Rafts: A New Mechanism Of Ethanol Action With Implications For Other Receptor-Mediated Effects, Gyongyi Szabo, Angela Dolganiuc, Qun Dai, Stephen Pruett
Tlr4, Ethanol, And Lipid Rafts: A New Mechanism Of Ethanol Action With Implications For Other Receptor-Mediated Effects, Gyongyi Szabo, Angela Dolganiuc, Qun Dai, Stephen Pruett
Gyongyi Szabo
Ethanol (EtOH) is the most widely abused substance in the United States, and it contributes to well-documented harmful (at high dosages) and beneficial (at low dosages) changes in inflammatory and immune responses. Lipid rafts have been implicated in the regulation and activation of several important receptor complexes in the immune system, including the TLR4 complex. Many questions remain about the precise mechanisms by which rafts regulate the assembly of these receptor complexes. Results summarized in this review indicate that EtOH acts by altering the LPS-induced redistribution of components of the TLR4 complex within the lipid raft and that this is …