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Regulation Of Polarized Protein Transport To Axons, Dendrites, And Sensory Cilia In Caeborhabditis Elegans Neurons, Tapan Apurva Maniar

Student Theses and Dissertations

Neurons are highly polarized cells, capable of receiving, processing and transmitting information, with the help of their specialized domains, an axon and one or more dendrites. The molecular dissimilarities between these domains are critical for neuronal function, and are a result of asymmetric trafficking of a large number of cellular components including ion channels, neurotransmitter receptors, synaptic vesicles, and signaling proteins. Yet, despite the significance of asymmetric protein transport in neuronal polarity, the molecules and mechanisms that direct polarized transport to axons, dendrites and cilia in neurons are only partly understood. In this thesis, I describe my effort at understanding …