Life Sciences Commons^™

Rapid Functional Dissection Of Genetic Networks Via Rnai In Mouse Embryos, Geulah Livshits

Student Theses and Dissertations

The development and maintenance of epithelial tissues is regulated by a complex array of signal cues from adjacent cells, the extracellular milieu and intracellular signaling cascades. In the mammalian epidermis, these cues instruct the specification and invagination of hair follicles as well as the stratification and turnover of the interfollicular epidermis. These processes rely on a coordinate balance of tissue growth, differentiation and regulation of cell-cell adhesion to maintain the integrity of the epithelium. Understanding the interplay between the various pathways controlling tissue development requires model systems that recapitulate the events that occur in vivo. Genetic studies in Drosophila and …