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The Impact Of Host Factors On Retroviral Evolution And The Identification Of A Novel Receptor That Was Used By An Ancient Primate Retrovirus, Steven J. Soll
The Impact Of Host Factors On Retroviral Evolution And The Identification Of A Novel Receptor That Was Used By An Ancient Primate Retrovirus, Steven J. Soll
Student Theses and Dissertations
The resurrection of inactive endogenous retroviruses allows us to learn about interactions between extinct pathogens and their hosts that occurred millions of years ago. Two of these paleoviruses, chimpanzee endogenous retrovirus 1 and 2 (CERV1 and CERV2), are relatives of modern murine leukemia viruses that are found in the genomes of a variety of old world primates, but are absent from the human genome. The nonexistence of human CERV1 and CERV2 homologues is peculiar given the numerous apparent cross-species transmissions that occurred between ancestors of old world monkeys, gorillas, and chimpanzees. It is possible that antiviral proteins were able to …