Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Cellular Trafficking And Processing Pathways Of The Alzheimer (Β)/A4 Amyloid Precursor Protein, Gregg L. Caporaso
Cellular Trafficking And Processing Pathways Of The Alzheimer (Β)/A4 Amyloid Precursor Protein, Gregg L. Caporaso
Student Theses and Dissertations
Extracellular deposition of the (β)/A4 amyloid peptide is a characteristic feature of the brain in patients with Alzheimer disease. (β)/A4 amyloid is derived from the integral membrane amyloid precursor protein (APP). Secreted truncated forms of A P P found in blood plasma and cerebrospinal fluid arise by proteolytic cleavage of APP within the (β)/A4 amyloid domain, precluding the possibility of amyloidogenesis for that population of molecules. The routes of APP processing were examined in metabolically labeled PC 12 cells treated with agents known to affect specific cellular functions. Treatment with either monensin or brefeldin A (BFA) prevented normal APP maturation …
Analysis Of Immediate-Early Gene Expression In The Songbird Brain Following Song Presentation, Claudio Vianna De Mello
Analysis Of Immediate-Early Gene Expression In The Songbird Brain Following Song Presentation, Claudio Vianna De Mello
Student Theses and Dissertations
The song system of oscine songbirds consists of the auditory and motor pathways used in the acquisition and production of learned song and provides powerful material for the study of neuronal and behavioral plasticity, both developmentally and during adult life. The purpose of this thesis is to begin to study molecular mechanisms underlying plasticity in the songbird brain. To test whether genomic mechanisms are involved, the expression of an immediate-early gene (lEG) was studied. The isolation of the canary ZENK homologue is described, an lEG that encodes a zinc-finger protein and which is highly sensitive to growth factors and depolarizing …
Mode Of Action Of Penicillin In Pneumococci: From Inhibition Of Cellular Targets To Bacterial Death, Philippe Moreillon
Mode Of Action Of Penicillin In Pneumococci: From Inhibition Of Cellular Targets To Bacterial Death, Philippe Moreillon
Student Theses and Dissertations
While the primary biochemical targets of β-lactams have been identified, the mechanisms by which inhibition of these targets (the membrane bound penicillin-binding proteins, or PBPs) leads to the irreversible antibacterial effects of these drugs have remained elusive. Treatment of Streptococcus pneumoniae with penicillin (or other cell wall inhibitors) results in a rapid sequence of events beginning with a slow-down and brief halt in bacterial growth, followed by rapid and irreversible reduction in the reproductive capacity (killing) of the cells, plus massive degradation (depolymerization and release) of the cell wall sacculus and release of cytoplasmic contents (bacterial lysis). By the end …