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Full-Text Articles in Life Sciences
A Statistical-Mechanical Model For The Binding Of Flexible Ligands To Proteins, Nora Dawn Laiken
A Statistical-Mechanical Model For The Binding Of Flexible Ligands To Proteins, Nora Dawn Laiken
Student Theses and Dissertations
In this dissertation, a theoretical model is presented for the binding of flexible ligands to proteins. The model explicitly accounts for the ability of these chain-like molecules to bind in a large number of configurations (including many in which not all segments are in contact with the protein) and therefore is quite different from the theory of multiple equilibria which commonly is used to analyze such interactions. The latter assumes that the ligands bind rigidly to point binding sites, neglecting the internal degrees of freedom of the bound molecules. Comparisons of binding data calculated using the present model with those …
Variability In The Firing Of Nerve Impulses In Eccentric Cells Of The Limulus Eye, Robert Shapley
Variability In The Firing Of Nerve Impulses In Eccentric Cells Of The Limulus Eye, Robert Shapley
Student Theses and Dissertations
Thesis is concerned with the source and characteristics of variability in the discharge of impulses by neurons. The neuron in which variability was studied is the eccentric cell in the compound eye of the horseshoe crab, Limulus polyphemus. In Part I a theory is presented which accounts for the variability in the response of an eccentric cell to light. The main idea of this theory is that the source of randomness in the impulse rate is "noise" in the generator potential. Another essential aspect of the theory is the view that the process which codes the generator potential into the …